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32259055 | Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38. | 2019 Jun 14 |
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26872382 | The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11. | 2016 Mar 29 |
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27286453 | UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response. | 2016 Jul 12 |
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24934408 | Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy. | 2014 Sep |
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| 5 |
23242585 | A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. | 2013 Jan |
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24038068 | Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor. | 2013 Nov |
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| 7 |
22446188 | Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. | 2012 Apr |
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| 8 |
22929806 | CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. | 2012 Oct 15 |
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22111927 | Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. | 2011 Dec 22 |
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| 10 |
19739070 | Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38. | 2010 Jun 15 |
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18820127 | 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. | 2009 Jan |
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| 12 |
18509065 | Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines. | 2008 Sep |
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18927314 | A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors. | 2008 Oct 15 |
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| 14 |
17431115 | S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells. | 2007 Apr |
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| 15 |
15699047 | The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. | 2005 Apr 8 |
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| 16 |
12370755 | Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38. | 2002 Nov |
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