Irinotecan

ATP binding cassette subfamily G member 2 (Junior blood group) ; Homo sapiens







134 Article(s)
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1 34718178 A nanotherapeutic strategy to overcome chemoresistance to irinotecan/7-ethyl-10-hydroxy-camptothecin in colorectal cancer. 2022 Jan 1 3
2 35192728 Poloxamer-linked prodrug of a topoisomerase I inhibitor SN22 shows efficacy in models of high-risk neuroblastoma with primary and acquired chemoresistance. 2022 Mar 1
3 33390536 Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial-Mesenchymal Transition in HCC827 Cells. 2021 4
4 33569416 Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells. 2021 Jan 2
5 34502348 The Second-Generation PIM Kinase Inhibitor TP-3654 Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs. 2021 Aug 30 3
6 34680166 Reversal of ABCG2/BCRP-Mediated Multidrug Resistance by 5,3',5'-Trihydroxy-3,6,7,4'-Tetramethoxyflavone Isolated from the Australian Desert Plant Eremophila galeata Chinnock. 2021 Oct 18 4
7 34830383 A Phenylfurocoumarin Derivative Reverses ABCG2-Mediated Multidrug Resistance In Vitro and In Vivo. 2021 Nov 19 1
8 31889589 Cetuximab enhances the efficiency of irinotecan through simultaneously inhibiting the MAPK signaling and ABCG2 in colorectal cancer cells. 2020 Feb 2
9 31975441 Regulation of breast cancer resistance protein and P-glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines. 2020 Apr 1
10 32143347 The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP. 2020 Mar 4 1
11 32326511 An Explorative Analysis of ABCG2/TOP-1 mRNA Expression as a Biomarker Test for FOLFIRI Treatment in Stage III Colon Cancer Patients: Results from Retrospective Analyses of the PETACC-3 Trial. 2020 Apr 15 1
12 32708825 ABCG2 Protein Levels and Association to Response to First-Line Irinotecan-Based Therapy for Patients with Metastatic Colorectal Cancer. 2020 Jul 16 4
13 33158067 Poziotinib Inhibits the Efflux Activity of the ABCB1 and ABCG2 Transporters and the Expression of the ABCG2 Transporter Protein in Multidrug Resistant Colon Cancer Cells. 2020 Nov 4 1
14 33692943 Establishment and Characterization of an Irinotecan-Resistant Human Colon Cancer Cell Line. 2020 2
15 30925062 Identification of Thienopyrimidine Scaffold as an Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach. 2019 May 9 2
16 27845419 ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia. 2018 Jan 1
17 29246888 Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines. 2018 Mar 3
18 29486476 Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells. 2018 1
19 29518481 Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. 2018 Jun 28 1
20 30075623 2,4,6-Substituted Quinazolines with Extraordinary Inhibitory Potency toward ABCG2. 2018 Sep 13 1
21 30166404 Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. 2018 Nov 8
22 30367935 β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer. 2018 Dec 1
23 28120346 2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations. 2017 Aug 2
24 28131876 Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib. 2017 May 1
25 28880238 Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review. 2017 Sep 7 6
26 28904007 Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2. 2017 Nov 1
27 28948511 SN38-PEG-PLGA-verapamil nanoparticles inhibit proliferation and downregulate drug transporter ABCG2 gene expression in colorectal cancer cells. 2017 Dec 2
28 29016119 9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein. 2017 Nov 9 1
29 26719532 Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer. 2016 Mar 1 5
30 26801902 Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines. 2016 Jan 22 4
31 27207776 Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers. 2016 Aug 1
32 27269636 Efflux transporter variants as predictors of drug toxicity in lung cancer patients: systematic review and meta-analysis. 2016 Jun 1
33 27280693 Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2). 2016 Jul 14 1
34 27698852 ABCG2 expression in colorectal adenocarcinomas may predict resistance to irinotecan. 2016 Oct 8
35 25855895 HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2). 2015 May 14 1
36 26206183 Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia. 2015 Sep 1 2
37 26352872 ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients. 2015 Dec 1
38 26386386 Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer. 2015 Nov 1 1
39 26516354 ABC-Transporter Expression Does Not Correlate with Response to Irinotecan in Patients with Metastatic Colorectal Cancer. 2015 2
40 26692923 FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models. 2015 3
41 24462359 Biofunctionalized polymer-lipid supported mesoporous silica nanoparticles for release of chemotherapeutics in multidrug resistant cancer cells. 2014 Apr 2
42 24523596 Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics. 2014 6
43 24726739 Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance. 2014 Jun 1
44 24781822 Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer. 2014 Apr 30 1
45 24932285 Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. 2014 Jun 2
46 24959385 Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer? 2014 4
47 25083297 Breast cancer resistance protein (BCRP) and excision repair cross complement-1 (ERCC1) expression in esophageal cancers and response to cisplatin and irinotecan based chemotherapy. 2014 Aug 3
48 25195021 Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method. 2014 Oct 15 2
49 25368234 Transcriptional targeting of human liver carboxylesterase (hCE1m6) and simultaneous expression of anti-BCRP shRNA enhances sensitivity of breast cancer cells to CPT-11. 2014 Nov 7
50 22882086 A template model for studying anticancer drug efflux transporter inhibitors in vitro. 2013 Oct 6