Irinotecan

ATP binding cassette subfamily C member 2 ; Homo sapiens







28 Article(s)
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1 35506159 Association of UGT1A1*6, UGT1A1*28, or ABCC2 c.3972C>T genetic polymorphisms with irinotecan-induced toxicity in Asian cancer patients: Meta-analysis. 2022 May 3 3
2 32778670 Effect of drug metabolizing enzymes and transporters in Thai colorectal cancer patients treated with irinotecan-based chemotherapy. 2020 Aug 10 1
3 29499902 Effect of UGT, SLCO, ABCB and ABCC polymorphisms on irinotecan toxicity. 2018 Dec 14 1
4 30360603 Effects of ABCC2 and SLCO1B1 Polymorphisms on Treatment Responses in Thai Metastatic Colorectal Cancer Patients Treated with Irinotecan-Based Chemotherapy 2018 Oct 26 1
5 25869015 Clinical validity of new genetic biomarkers of irinotecan neutropenia: an independent replication study. 2016 Feb 1
6 27269636 Efflux transporter variants as predictors of drug toxicity in lung cancer patients: systematic review and meta-analysis. 2016 Jun 1
7 25554586 Report of new haplotype for ABCC2 gene: rs17222723 and rs8187718 in cis. 2015 Mar 1
8 26352872 ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients. 2015 Dec 1
9 23811769 [Role of ABC efflux transporters in the oral bioavailability and drug-induced intestinal toxicity]. 2013 1
10 23953030 A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO). 2013 Nov 4
11 21687948 'Genetic profiling' and ovarian cancer therapy (review). 2011 Sep-Oct 1
12 20602618 Irinotecan pharmacogenomics. 2010 Jul 1
13 19349540 Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. 2009 Jun 1 1
14 18418374 Pharmacogenetic pathway analysis of irinotecan. 2008 Sep 1
15 18690847 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. 2008 Aug 1
16 18981587 Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI). 2008 Nov 10
17 17185998 Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. 2007 Jan 6
18 17534875 Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. 2007 Jul 1 2
19 16271446 Pharmacogenetics of irinotecan metabolism and transport: an update. 2006 Mar 2
20 16343744 Role of pharmacogenetics in irinotecan therapy. 2006 Mar 8 1
21 16508919 Expression of drug pathway proteins is independent of tumour type. 2006 Jun 1
22 15801936 Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer. 2005 Apr 1
23 16132345 Human multidrug resistance associated protein 4 confers resistance to camptothecins. 2005 Nov 4
24 12914384 Pharmacogenetics of stomach cancer. 2003 Sep-Oct 1
25 12199631 Influence of anticonvulsants on the metabolism and elimination of irinotecan. A North American Brain Tumor Consortium preliminary report. 2002 Aug 3
26 15618649 The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. 2002 4
27 10378768 An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. 1999 Apr 26 2
28 10695015 [Mechanisms for resistance to anticancer agents and the reversal of the resistance]. 1999 Sep 2