Protein Name mitogen-activated protein kinase 14
Organism Homo sapiens
Gene ID 1432
Gene Symbol


UniProt Q16539 (MK14_HUMAN), B4E0K5 (B4E0K5_HUMAN), L7RSM2 (L7RSM2_HUMAN), A0A024RD15 (A0A024RD15_HUMAN)
Relationships Total Number of functionally related compound(s) : 3132
Total Number of Articles : 7250

mitogen-activated protein kinase 14

Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

  • mitogen-activated protein kinase 14
  • CSAID-binding protein
  • MAP kinase 14
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