Irinotecan

tumor associated calcium signal transducer 2 ; Homo sapiens







22 Article(s)
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Title
Pub. Year
#Total Relationships
1 35530278 Shedding light on triple-negative breast cancer with Trop2-targeted antibody-drug conjugates. 2022 3
2 35545724 Analysis of patients without and with an initial triple-negative breast cancer diagnosis in the phase 3 randomized ASCENT study of sacituzumab govitecan in metastatic triple-negative breast cancer. 2022 May 11 1
3 35624189 Selection of Payloads for Antibody-Drug Conjugates Targeting Ubiquitously Expressed Tumor-Associated Antigens: a Case Study. 2022 May 27 1
4 33882206 Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer. 2021 Apr 22 1
5 34116144 Biomarker analyses in the phase III ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer. 2021 Sep 1
6 34176192 Sacituzumab Govitecan for Metastatic Triple-Negative Breast Cancer: Clinical Overview and Management of Potential Toxicities. 2021 Oct 3
7 34651524 Tackling metastatic triple-negative breast cancer with sacituzumab govitecan. 2021 Dec 2
8 31891442 Sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2, shows cytotoxic activity against poorly differentiated endometrial adenocarcinomas in vitro and in vivo. 2020 Mar 2
9 32082489 Preclinical activity of sacituzumab govitecan (IMMU-132) in uterine and ovarian carcinosarcomas. 2020 Feb 4 2
10 32117765 Preclinical Activity of Sacituzumab Govitecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) Linked to the Active Metabolite of Irinotecan (SN-38), in Ovarian Cancer. 2020 4
11 32529410 Sacituzumab Govitecan: First Approval. 2020 Jul 1
12 31208270 Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan. 2019 Aug/Sep 2
13 29989029 The emergence of trophoblast cell-surface antigen 2 (TROP-2) as a novel cancer target. 2018 Jun 22 2
14 28291390 Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer. 2017 Jul 1 2
15 28548889 Therapy of Advanced Non-Small-Cell Lung Cancer With an SN-38-Anti-Trop-2 Drug Conjugate, Sacituzumab Govitecan. 2017 Aug 20 2
16 28679770 Therapy of Small Cell Lung Cancer (SCLC) with a Topoisomerase-I-inhibiting Antibody-Drug Conjugate (ADC) Targeting Trop-2, Sacituzumab Govitecan. 2017 Oct 1 1
17 26541586 Sacituzumab Govitecan, a Novel Antibody--Drug Conjugate, in Patients With Metastatic Platinum-Resistant Urothelial Carcinoma. 2016 Feb 2
18 26577300 An ADC for Triple-Negative Breast Cancer. 2016 Jan 2
19 27207776 Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers. 2016 Aug 2
20 25944802 First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors. 2015 Sep 1 3
21 26101915 Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC). 2015 Sep 8 1
22 21372224 Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. 2011 May 15 4