| Protein Name | tyrosyl-DNA phosphodiesterase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55775 |
| Gene Symbol | TDP1 |
| UniProt | Q9NUW8 (TYDP1_HUMAN), A0A024R6L5 (A0A024R6L5_HUMAN), G3V2F4 (G3V2F4_HUMAN), B3KN41 (B3KN41_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
208
Total Number of Articles : 136 |
Description |
tyrosyl-DNA phosphodiesterase 1 |
| Gene Summary |
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016] |
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| Properties | |