Protein Name | ATP-binding cassette, sub-family B member 1B |
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Organism | Rattus norvegicus |
Gene ID | 24646 |
Gene Symbol | Abcb1b |
UniProt | Q8R427 (Q8R427_RAT) |
Relationships |
Total Number of functionally related compound(s) :
765
Total Number of Articles : 1099 |
Description |
ATP-binding cassette, sub-family B member 1B |
Gene Summary |
Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; animal organ development; and cellular response to external biotic stimulus. Located in Golgi membrane and external side of apical plasma membrane. Used to study brain disease (multiple); colorectal adenocarcinoma; end stage renal disease; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; non-alcoholic fatty liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022] |
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