| 1 |
33402591 | Optimum patient selection for irinotecan-containing regimens in metastatic colorectal cancer: Literature review and lessons from clinical practice. | 2021 Jan-Mar |
1 |
| 2 |
30377777 | Dose adjustment of irinotecan based on UGT1A1 polymorphisms in patients with colorectal cancer. | 2019 Jan |
1 |
| 3 |
29487697 | DPYD and UGT1A1 genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer. | 2018 Jan 30 |
1 |
| 4 |
29499902 | Effect of UGT, SLCO, ABCB and ABCC polymorphisms on irinotecan toxicity. | 2018 Dec 14 |
4 |
| 5 |
29649683 | Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems. | 2018 Jun |
1 |
| 6 |
29728798 | UGT1A polymorphisms associated with worse outcome in colorectal cancer patients treated with irinotecan-based chemotherapy. | 2018 Jul |
3 |
| 7 |
29861877 | SNPs in predicting clinical efficacy and toxicity of chemotherapy: walking through the quicksand. | 2018 May 18 |
2 |
| 8 |
29891024 | Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation. | 2018 |
1 |
| 9 |
28157715 | Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1. | 2017 Jun 20 |
1 |
| 10 |
28637434 | Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis. | 2017 Jun 20 |
1 |
| 11 |
29098099 | Life-Threatening Irinotecan-Induced Toxicity in an Adult Patient with Alveolar Rhabdomyosarcoma: The Role of a UGT1A1 Polymorphism. | 2017 |
1 |
| 12 |
25055799 | UGT1A1 *6 polymorphism predicts outcome in elderly patients with relapsed or refractory diffuse large B-cell lymphoma treated with carboplatin, dexamethasone, etoposide and irinotecan. | 2015 Jan |
4 |
| 13 |
25880011 | An internally and externally validated nomogram for predicting the risk of irinotecan-induced severe neutropenia in advanced colorectal cancer patients. | 2015 May 12 |
4 |
| 14 |
26027741 | Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy. | 2015 May |
1 |
| 15 |
24453052 | Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations. | 2014 Jun |
6 |
| 16 |
24834123 | Polymorphisms of uridine glucuronosyltransferase gene and irinotecan toxicity: low dose does not protect from toxicity. | 2014 |
3 |
| 17 |
24897286 | Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers. | 2014 Apr |
3 |
| 18 |
25175642 | A novel system for predicting the toxicity of irinotecan based on statistical pattern recognition with UGT1A genotypes. | 2014 Oct |
1 |
| 19 |
23303296 | Polymorphisms of the UDP-glucuronosyl transferase 1A genes are associated with adverse events in cancer patients receiving irinotecan-based chemotherapy. | 2013 Feb |
5 |
| 20 |
23386248 | Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens. | 2013 Apr |
3 |
| 21 |
23985249 | [Relationship between UGT1A and irinotecan-related toxicity]. | 2013 Apr |
1 |
| 22 |
22535333 | The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinotecan-based regimens. | 2012 Jun |
1 |
| 23 |
22740978 | Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene. | 2012 Mar |
7 |
| 24 |
23631285 | Predictors of irinotecan toxicity and efficacy in treatment of metastatic colorectal cancer. | 2012 |
2 |
| 25 |
21366639 | Barking up the wrong genome--we are not alone. | 2011 Apr |
1 |
| 26 |
21617725 | Concurrence of UGT1A polymorphism and end-stage renal disease leads to severe toxicities of irinotecan in a patient with metastatic colon cancer. | 2011 Mar-Apr |
6 |
| 27 |
19932091 | Rapid UGT1A1 (TA)(n) genotyping by high resolution melting curve analysis for Gilbert's syndrome diagnosis. | 2010 Feb |
1 |
| 28 |
20205661 | Pharmacogenetics in oncology: a promising field. | 2010 |
1 |
| 29 |
20580994 | The UGT1A1*28 polymorphism correlates with erlotinib's effect on SN-38 glucuronidation. | 2010 Jul |
1 |
| 30 |
20628391 | UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy. | 2010 Aug 10 |
2 |
| 31 |
19151561 | [Lung cancer]. | 2009 Jan |
1 |
| 32 |
19415281 | Pharmacokinetic analysis of irinotecan plus bevacizumab in patients with advanced solid tumors. | 2009 Dec |
2 |
| 33 |
19620803 | Individual differences in rate-limiting reactions during metabolism of irinotecan hydrochloride. | 2009 Jul |
10 |
| 34 |
19644023 | Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology. | 2009 Sep |
2 |
| 35 |
19712005 | UGT1A1, UGT1A6 and UGT1A7 genetic analysis: repercussion for irinotecan pharmacogenetics in the São Miguel Island Population (Azores, Portugal). | 2009 |
1 |
| 36 |
17549477 | Involvement of UDP-glucuronosyltransferase activity in irinotecan-induced delayed-onset diarrhea in rats. | 2008 Apr |
1 |
| 37 |
18349289 | Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk. | 2008 Mar |
3 |
| 38 |
18467239 | UGT1A1*28 and other UGT1A polymorphisms as determinants of irinotecan toxicity. | 2008 Apr |
1 |
| 39 |
18832463 | Rapid allelic discrimination by TaqMan PCR for the detection of the Gilbert's syndrome marker UGT1A1*28. | 2008 Nov |
1 |
| 40 |
17529881 | Insights, challenges, and future directions in irinogenetics. | 2007 Jun |
2 |
| 41 |
17558305 | Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28. | 2007 Jul |
5 |
| 42 |
18478930 | [Polymorphisms of UGT1A gene and irinotecan toxicity in Chinese colorectal cancer patients]. | 2007 Dec |
2 |
| 43 |
16314881 | Comparative genomics analysis of human sequence variation in the UGT1A gene cluster. | 2006 Jan-Feb |
1 |
| 44 |
16343744 | Role of pharmacogenetics in irinotecan therapy. | 2006 Mar 8 |
1 |
| 45 |
16636344 | Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. | 2006 May 20 |
2 |
| 46 |
16877259 | Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan. | 2006 |
3 |
| 47 |
16969123 | Hepatic transport, metabolism and biliary excretion of irinotecan in a cancer patient with an external bile drain. | 2006 Sep |
1 |
| 48 |
15709193 | UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. | 2005 Feb 1 |
2 |
| 49 |
15833930 | Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms. | 2005 Jul |
1 |
| 50 |
16166450 | Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes. | 2005 Sep 15 |
4 |