| Protein Name | ATP binding cassette subfamily G member 2 (JR blood group) |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9429 |
| Gene Symbol | ABCG2 |
| UniProt | Q9UNQ0 (ABCG2_HUMAN), A1LUE4 (A1LUE4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1370
Total Number of Articles : 2117 |
Description |
ATP binding cassette subfamily G member 2 (JR blood group) |
| Gene Summary |
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
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