Irinotecan

caspase 3 ; Homo sapiens







18 Article(s)
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1 33995089 Case Report: 7-Ethyl-10-Hydroxycamptothecin, a DNA Topoisomerase I Inhibitor, Performs BRD4 Inhibitory Activity and Inhibits Human Leukemic Cell Growth. 2021 1
2 32033066 Antagonistic Effects of CAPE (a Component of Propolis) on the Cytotoxicity and Genotoxicity of Irinotecan and SN38 in Human Gastrointestinal Cancer Cells In Vitro. 2020 Feb 4 1
3 33138058 Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy. 2020 Oct 29 1
4 22471369 Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. 2012 May 3
5 23155248 Analysis of type of cell death induced by topoisomerase inhibitor SN-38 in human oral squamous cell carcinoma cell lines. 2012 Nov 1
6 21609311 Topoisomerase I inhibitor SN-38 effectively attenuates growth of human non-small cell lung cancer cell lines in vitro and in vivo. 2011 1
7 20704575 Combination of RET siRNA and irinotecan inhibited the growth of medullary thyroid carcinoma TT cells and xenografts via apoptosis. 2010 Apr 2
8 21042746 Effects of the HDAC inhibitor CG2 in combination with irinotecan, 5-fluorouracil, or oxaliplatin on HCT116 colon cancer cells and xenografts. 2010 Dec 1
9 17395183 Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells. 2007 Apr 17 1
10 17609585 Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis. 2007 Jul 1
11 16827119 Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms. 2006 May-Jun 1
12 16010439 Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms. 2005 Aug 2
13 16491956 Irinotecan/5-fluorouracil combination induces alterations in mitochondrial membrane potential and caspases on colon cancer cell lines. 2005 1
14 15213307 Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression. 2004 Jul 1
15 11351255 Effect of inhibitors of cysteine and serine proteases in anticancer drug-induced apoptosis in gastric cancer cells. 2001 Jun 1
16 11751522 Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. 2001 Dec 1
17 10738246 Ectopic p16(ink4) expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells. 2000 Apr 15 2
18 20650253 Involvement of CPP32/Yama-like protease in CPT-11-induced death signal transduction pathway. 1996 Dec 4