| Protein Name | ATP binding cassette subfamily B member 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5243 |
| Gene Symbol | ABCB1 |
| UniProt | P08183 (MDR1_HUMAN), A4D1D2 (A4D1D2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
3985
Total Number of Articles : 9090 |
Description |
ATP binding cassette subfamily B member 1 |
| Gene Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] |
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