Sirolimus


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2874 Functionally related protein(s)
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Protein Name
UniProt Entry
Gene Symbol
Organism
NCBI Gene ID
# All related compound(s)
#Article(s)
1 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 2470
2 CREB regulated transcription coactivator 1 CRTC1_MOUSE Crtc1 Mus musculus 382056 993 1181
3 mechanistic target of rapamycin kinase MTOR_MOUSE Mtor Mus musculus 56717 1120 573
4 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 444
5 ribosomal protein S6 kinase B1 KS6B1_HUMAN RPS6KB1 Homo sapiens 6198 764 298
6 mechanistic target of rapamycin kinase MTOR_RAT Mtor Rattus norvegicus 56718 809 284
7 CREB regulated transcription coactivator 2 CRTC2_MOUSE Crtc2 Mus musculus 74343 347 166
8 insulin INS_HUMAN INS Homo sapiens 3630 7950 158
9 TSC complex subunit 1 TSC1_HUMAN TSC1 Homo sapiens 7248 220 123
10 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 105
11 eukaryotic translation initiation factor 4E binding protein 1 4EBP1_HUMAN EIF4EBP1 Homo sapiens 1978 300 103
12 ribosomal protein S6 kinase B1 KS6B1_RAT Rps6kb1 Rattus norvegicus 83840 301 99
13 TSC complex subunit 2 TSC2_HUMAN TSC2 Homo sapiens 7249 222 90
14 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 84
15 calcineurin binding protein 1 CABIN_HUMAN CABIN1 Homo sapiens 23523 118 81
16 ribosomal protein S6 kinase, polypeptide 1 KS6B1_MOUSE Rps6kb1 Mus musculus 72508 289 70
17 CD4 molecule CD4_HUMAN CD4 Homo sapiens 920 2744 64
18 tumor necrosis factor TNFA_HUMAN TNF Homo sapiens 7124 8006 61
19 LIM domain binding 3 LDB3_HUMAN LDB3 Homo sapiens 11155 28 59
20 interleukin 2 IL2_HUMAN IL2 Homo sapiens 3558 2456 58
21 hypoxia inducible factor 1 subunit alpha HIF1A_HUMAN HIF1A Homo sapiens 3091 2152 55
22 TSC complex subunit 1 TSC1_MOUSE Tsc1 Mus musculus 64930 71 53
23 AKT serine/threonine kinase 1 AKT1_RAT Akt1 Rattus norvegicus 24185 2385 53
24 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 50
25 forkhead box P3 FOXP3_HUMAN FOXP3 Homo sapiens 50943 549 49
26 transforming growth factor beta 1 TGFB1_HUMAN TGFB1 Homo sapiens 7040 2953 49
27 phosphatase and tensin homolog PTEN_HUMAN PTEN Homo sapiens 5728 1316 47
28 eukaryotic translation initiation factor 4E IF4E_HUMAN EIF4E Homo sapiens 1977 399 45
29 cytochrome P450 family 3 subfamily A member 4 CP3A4_HUMAN CYP3A4 Homo sapiens 1576 3475 43
30 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 43
31 CD8a molecule CD8A_HUMAN CD8A Homo sapiens 925 1925 42
32 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 41
33 FKBP prolyl isomerase 1A pseudogene 4 - FKBP1AP4 Homo sapiens 2285 113 40
34 insulin like growth factor 1 IGF1_HUMAN IGF1 Homo sapiens 3479 1917 40
35 mitogen-activated protein kinase 3 MK03_HUMAN MAPK3 Homo sapiens 5595 3238 39
36 TSC complex subunit 2 Q3UHB2_MOUSE Tsc2 Mus musculus 22084 99 38
37 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 37
38 insulin receptor substrate 1 IRS1_HUMAN IRS1 Homo sapiens 3667 493 35
39 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 34
40 interferon gamma IFNG_HUMAN IFNG Homo sapiens 3458 3371 33
41 RAR related orphan receptor C RORG_HUMAN RORC Homo sapiens 6097 199 33
42 CREB regulated transcription coactivator 1 CRTC1_HUMAN CRTC1 Homo sapiens 23373 120 33
43 beclin 1 BECN1_HUMAN BECN1 Homo sapiens 8678 847 31
44 FKBP prolyl isomerase 1A FKB1A_HUMAN FKBP1A Homo sapiens 2280 68 31
45 transcriptional regulating factor 1 TREF1_HUMAN TRERF1 Homo sapiens 55809 54 30
46 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PK3CD_HUMAN PIK3CD Homo sapiens 5293 775 29
47 vascular endothelial growth factor A VEGFA_MOUSE Vegfa Mus musculus 22339 1647 29
48 CD4 antigen CD4_MOUSE Cd4 Mus musculus 12504 1594 29
49 interleukin 2 IL2_MOUSE Il2 Mus musculus 16183 1527 29
50 Target of rapamycin TOR_DROME Tor Drosophila melanogaster 47396 54 29