| 1 |
33991364 | Increased systemic exposure of once-daily tacrolimus in renal transplant recipients on marine omega-3 fatty acid supplementation. | 2021 Jul |
1 |
| 2 |
33115392 | The Genetic Polymorphism of CYP3A4 rs2242480 is Associated with Sirolimus Trough Concentrations Among Adult Renal Transplant Recipients. | 2020 |
1 |
| 3 |
30295407 | Effect of isavuconazole on tacrolimus and sirolimus serum concentrations in allogeneic hematopoietic stem cell transplant patients: A drug-drug interaction study. | 2019 Feb |
1 |
| 4 |
28355970 | Clinical impact and management of fluconazole discontinuation on sirolimus levels in bone marrow transplant patients. | 2018 Apr |
1 |
| 5 |
29668485 | Prolonged activity and toxicity of sirolimus in a patient with metastatic renal perivascular epithelioid cell tumor: a case report and literature review. | 2018 Jul |
1 |
| 6 |
28676933 | Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer. | 2017 Sep |
2 |
| 7 |
28700521 | Effect of CYP3A4 and CYP3A5 Genetic Polymorphisms on the Pharmacokinetics of Sirolimus in Healthy Chinese Volunteers. | 2017 Aug |
6 |
| 8 |
28722255 | Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. | 2017 Oct |
1 |
| 9 |
27501453 | Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. | 2016 Aug |
1 |
| 10 |
27530708 | Increased inhibition of cytochrome P450 3A4 with the tablet formulation of posaconazole. | 2016 Oct |
2 |
| 11 |
25162215 | Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. | 2015 Jun |
1 |
| 12 |
25599164 | Safety of voriconazole and sirolimus coadministration after allogeneic hematopoietic SCT. | 2015 Mar |
2 |
| 13 |
26151793 | Serum Sirolimus Level Elevation Induced by Acitretin: Report of a Novel Drug-Drug Interaction. | 2015 Jul |
1 |
| 14 |
26225230 | Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants. | 2015 Feb |
1 |
| 15 |
26232156 | A clinical approach to solving discrepancies in therapeutic drug monitoring results for patients on sirolimus or tacrolimus: Towards personalized medicine, immunosuppression and pharmacogenomics. | 2015 Oct 23 |
1 |
| 16 |
26256674 | The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model. | 2015 Dec |
2 |
| 17 |
24575309 | Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient. | 2014 |
1 |
| 18 |
27128230 | The effect of rifampin on the pharmacokinetics of sirolimus in healthy volunteers. | 2014 Jan |
3 |
| 19 |
23884207 | Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content. | 2013 Jul 24 |
1 |
| 20 |
23974086 | Effect of CYP3A4*22, POR*28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients. | 2013 Dec |
1 |
| 21 |
22564264 | Safety of posaconazole and sirolimus coadministration in allogeneic hematopoietic stem cell transplants. | 2012 Sep |
4 |
| 22 |
22016125 | [Drug interactions and immunosuppression in organ transplant recipients]. | 2011 Oct 18 |
1 |
| 23 |
22094953 | Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients. | 2011 Dec 27 |
1 |
| 24 |
19709321 | Effect of coadministered HIV-protease inhibitors on tacrolimus and sirolimus blood concentrations in a kidney transplant recipient. | 2009 Aug |
1 |
| 25 |
19728747 | Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions. | 2009 |
1 |
| 26 |
18458675 | Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus. | 2008 Jun 3 |
3 |
| 27 |
18721002 | Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers. | 2008 |
1 |
| 28 |
17889118 | Pharmacogenetics of tacrolimus and sirolimus in renal transplant patients: from retrospective analyses to prospective studies. | 2007 Sep |
2 |
| 29 |
17913896 | Pharmacokinetic profile of temsirolimus with concomitant administration of cytochrome p450-inducing medications. | 2007 Nov |
1 |
| 30 |
18094423 | Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma. | 2007 Dec 15 |
1 |
| 31 |
14569063 | CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. | 2004 Jan |
3 |
| 32 |
15158963 | Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. | 2004 Jun 11 |
4 |
| 33 |
15307840 | CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. | 2004 Sep |
3 |
| 34 |
15385826 | New insights into drug absorption: studies with sirolimus. | 2004 Oct |
4 |
| 35 |
15686733 | Clinical relevance of sirolimus drug interactions in transplant patients. | 2004 Dec |
2 |
| 36 |
15760093 | Exposure-response relationships and drug interactions of sirolimus. | 2004 Oct 15 |
2 |
| 37 |
14529371 | Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. | 2003 Oct |
4 |
| 38 |
11907172 | Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion. | 2002 Apr |
4 |
| 39 |
12469693 | Sirolimus: new preparation. No tangible advance in renal transplantation. | 2002 Dec |
1 |
| 40 |
11180036 | Pharmacokinetic interaction between single oral doses of diltiazem and sirolimus in healthy volunteers. | 2001 Jan |
1 |
| 41 |
11384247 | Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. | 2001 Jun 7 |
3 |
| 42 |
9618413 | Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. | 1998 Jun |
6 |
| 43 |
7628296 | Human liver cytochrome P4503A biotransformation of the cyclosporin derivative SDZ IMM 125. | 1995 Mar |
1 |