Protein Name TSC complex subunit 2
Organism Homo sapiens
Gene ID 7249
Gene Symbol

TSC2

UniProt P49815 (TSC2_HUMAN), Q5HYF7 (Q5HYF7_HUMAN), B3KWH7 (B3KWH7_HUMAN), H3BMQ0 (H3BMQ0_HUMAN), X5D7Q2 (X5D7Q2_HUMAN)
Relationships Total Number of functionally related compound(s) : 222
Total Number of Articles : 361
Description

TSC complex subunit 2

Gene Summary

This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis. [provided by RefSeq, May 2022]

synonyms
  • tuberin
  • protein phosphatase 1, regulatory subunit 160
  • tuberous sclerosis 2 protein
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Properties