Sirolimus

CREB regulated transcription coactivator 2 ; Mus musculus







166 Article(s)
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1 34585416 Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators. 2022 May 1
2 34757123 Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via β2-arrestin link to mTOR pathway. 2022 Mar 1
3 34866401 Exercise increases phosphorylation of the putative mTORC2 activity readout NDRG1 in human skeletal muscle. 2022 Jan 1 2
4 34949833 The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis. 2022 Feb 1
5 35219732 mTOR as an eligible molecular target for possible pharmacological treatment of nonalcoholic steatohepatitis. 2022 Apr 15 1
6 35238644 Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss. 2022 Mar 8 1
7 35361526 Protein kinase C: release from quarantine by mTORC2. 2022 Jun 1
8 35488725 Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO. 2022 Jun 1
9 35579957 mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. 2022 May 17 1
10 32394479 Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies. 2021 Jan 1
11 33444645 mTORC2/Rictor is essential for coelomocyte endocytosis in Apostichopus japonicus. 2021 May 1
12 33452321 Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration. 2021 Jan 15 1
13 33547375 Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43. 2021 Nov 1
14 33674554 Surgical procedures suppress autophagic flux in the kidney. 2021 Mar 5 1
15 33872697 Glucagon transiently stimulates mTORC1 by activation of an EPAC/Rap1 signaling axis. 2021 Aug 1
16 33976205 Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. 2021 May 11 1
17 34103528 PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. 2021 Jun 8 1
18 34130715 Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription. 2021 Jun 15 1
19 34155681 Rictor Is a Novel Regulator of TRAF6/TRAF3 in Osteoclasts. 2021 Oct 1
20 34209274 Aversive Learning Deficits and Depressive-Like Behaviors Are Accompanied by an Increase in Oxidative Stress in a Rat Model of Fetal Alcohol Spectrum Disorders: The Protective Effect of Rapamycin. 2021 Jun 30 1
21 34354602 Rapalink-1 Increased Infarct Size in Early Cerebral Ischemia-Reperfusion With Increased Blood-Brain Barrier Disruption. 2021 1
22 34551966 TLR-4 Agonist Induces IFN-γ Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway. 2021 Nov 1 1
23 34610303 Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase. 2021 Oct 5 1
24 34626605 N-acetyl l-aspartate and Triacetin modulate tumor suppressor MicroRNA and class I and II HDAC gene expression induce apoptosis in Glioblastoma cancer cells in vitro. 2021 Dec 1 1
25 34650053 mTORC2 confers neuroprotection and potentiates immunity during virus infection. 2021 Oct 14 1
26 34699314 LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis. 2021 Dec 1
27 34769253 Activation of ERK and p38 Reduces AZD8055-Mediated Inhibition of Protein Synthesis in Hepatocellular Carcinoma HepG2 Cell Line. 2021 Oct 30 1
28 34805133 Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome. 2021 1
29 34858182 Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension. 2021 4
30 34986526 The mechanism of rapamycin in promoting asthmatic regulatory T cell differentiation and function. 2021 Oct 25 2
31 35174167 Role of ARHGEF3 as a GEF and mTORC2 Regulator. 2021 2
32 30794726 Next Generation Strategies for Geroprotection via mTORC1 Inhibition. 2020 Jan 1 2
33 31509054 Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen. 2020 May 18 1
34 31699566 Growth Factor-Dependent and -Independent Activation of mTORC2. 2020 Jan 1
35 31738412 STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in diabetic mice. 2020 Nov 1 1
36 31825077 Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction. 2020 Jan 17 1
37 32023458 Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab. 2020 Feb 4 1
38 32035060 mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy. 2020 Apr 1
39 32046043 Silencing of PARP2 Blocks Autophagic Degradation. 2020 Feb 7 1
40 32579497 mTORC and PKCε in Regulation of Alcohol Use Disorder. 2020 1
41 32647003 HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. 2020 Jul 10 1
42 32666017 The mTORC2 Component Rictor Is Required for Load-Induced Bone Formation in Late-Stage Skeletal Cells. 2020 Jul 1
43 32720643 Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging. 2020 Jul 28 1
44 32905798 Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle. 2020 Oct 6 1
45 32923403 mTOR Promotes Tissue Factor Expression and Activity in EGFR-Mutant Cancer. 2020 1
46 33013932 Regulation of RLR-Mediated Antiviral Responses of Human Dendritic Cells by mTOR. 2020 1
47 33033115 Ras, PI3K and mTORC2 - three's a crowd? 2020 Oct 8 1
48 33125102 PTH(1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway. 2020 Dec 1
49 33174028 S100A8 and S100A9 promote endothelial cell activation through the RAGE‑mediated mammalian target of rapamycin complex 2 pathway. 2020 Dec 1
50 33183203 Nicotinamide: Oversight of Metabolic Dysfunction Through SIRT1, mTOR, and Clock Genes. 2020 1