Sirolimus

thymoma viral proto-oncogene 1 ; Mus musculus







105 Article(s)
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1 34370147 Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model. 2022 Jan 2
2 34902496 Autophagy of Spinal Microglia Affects the Activation of Microglia through the PI3K/AKT/mTOR Signaling Pathway. 2022 Feb 1 1
3 34922249 Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway. 2022 Feb 1
4 35235160 AKT/GSK-3β signaling is altered through downregulation of mTOR during cerebral Ischemia/Reperfusion injury. 2022 May 1
5 35238644 Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss. 2022 Mar 8 1
6 35449295 Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling. 2022 May 1
7 33352197 Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes. 2021 Feb 2
8 33383488 Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis. 2021 Apr 1
9 33469286 Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer. 2021 1
10 33949020 SETD2 epidermal deficiency promotes cutaneous wound healing via activation of AKT/mTOR Signalling. 2021 Jun 1
11 34275490 Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture. 2021 Jul 19 1
12 34416638 Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt/mTOR/HIF 1α signaling pathway. 2021 Aug 17 1
13 34610303 Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase. 2021 Oct 5 1
14 34689241 Assessment of tantalum nanoparticle-induced MC3T3-E1 proliferation and underlying mechanisms. 2021 Oct 23 8
15 34819120 Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma. 2021 Nov 24 1
16 34853727 Tubule-specific deletion of LincRNA-p21ameliorates lipotoxic kidney injury. 2021 Dec 3 1
17 34986526 The mechanism of rapamycin in promoting asthmatic regulatory T cell differentiation and function. 2021 Oct 25 1
18 31666191 Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56. 2020 Feb 1
19 31738412 STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in diabetic mice. 2020 Nov 1 3
20 32167156 Low-concentration DMSO accelerates skin wound healing by Akt/mTOR-mediated cell proliferation and migration in diabetic mice. 2020 Jul 1
21 32353830 Implications of maraviroc and/or rapamycin in a mouse model of fragility. 2020 Apr 30 1
22 32397282 Therapeutic Effect of Rapamycin on Aortic Dissection in Mice. 2020 May 8 1
23 32421368 Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR. 2020 Jul 1 1
24 32599128 Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice. 2020 Sep 1
25 32635337 A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of Tumor Cell PD-L1 Involved in Immune Escape. 2020 Jul 3 2
26 32878988 Branched-chain ketoacid overload inhibits insulin action in the muscle. 2020 Nov 13 1
27 33038070 Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation. 2020 Oct 1
28 33243998 Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy. 2020 Nov 26 1
29 29790114 Ivabradine improved left ventricular function and pressure overload-induced cardiomyocyte apoptosis in a transverse aortic constriction mouse model. 2019 Jan 1
30 30053339 Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR. 2019 Jan 1
31 30905858 Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cells. 2019 Aug 2
32 31042058 A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. 2019 Jul 1 1
33 31167789 Mature osteoclast-derived apoptotic bodies promote osteogenic differentiation via RANKL-mediated reverse signaling. 2019 Jul 19 1
34 31182914 Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer. 2019 3
35 31363142 Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency. 2019 Jul 30 1
36 31798451 NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer's Disease. 2019 1
37 31820607 [Moxibustion at acpoints of governor vessel on regulating PI3K/Akt/mTOR signaling pathway and enhancing autophagy process in APP/PS1 double-transgenic Alzheimer's disease mice]. 2019 Dec 12 5
38 29257864 Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways. 2018 Apr 18 2
39 29562463 [Rapamycin affect the apoptosis of splenic CD4+CD25+ regulatory T cells of mouse severe aplastic anemia model]. 2018 Mar 14 1
40 30205205 Rapamycin and fingolimod modulate Treg/Th17 cells in experimental autoimmune encephalomyelitis by regulating the Akt-mTOR and MAPK/ERK pathways. 2018 Nov 15 1
41 30442153 Ca2+-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling. 2018 Nov 15 1
42 27903739 Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming. 2017 Jan 1 1
43 28117338 Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes. 2017 Jan 24 1
44 28165011 mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. 2017 Feb 6 1
45 28182002 Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease. 2017 Feb 9 1
46 28373901 Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK. 2017 2
47 28746918 Differential Role of Rapamycin in Epidermis-Induced IL-15-IGF-1 Secretion via Activation of Akt/mTORC2. 2017 1
48 28814333 Rapamycin Prevents cyclophosphamide-induced Over-activation of Primordial Follicle pool through PI3K/Akt/mTOR Signaling Pathway in vivo. 2017 Aug 16 3
49 26733005 Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice. 2016 Mar 1
50 26801880 Inhibition of Akt Enhances the Chemopreventive Effects of Topical Rapamycin in Mouse Skin. 2016 Mar 3