Sirolimus

tumor protein p53 ; Homo sapiens







37 Article(s)
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1 35356282 Advanced Oxidative Protein Products Drive Trophoblast Cells Into Senescence by Inhibiting the Autophagy: The Potential Implication of Preeclampsia. 2022 1
2 35589683 Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamics. 2022 May 19 1
3 33040459 EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53. 2021 Jan 1
4 33614662 Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by Inhibition of p53 and Phosphorylated HSP27. 2021 2
5 33860865 Activated p53 in the anti-apoptotic milieu of tuberous sclerosis gene mutation induced diseases leads to cell death if thioredoxin reductase is inhibited. 2021 Jun 1
6 34948101 Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA. 2021 Dec 10 1
7 29871517 Hypoxic Preconditioning Protects SH-SY5Y Cell against Oxidative Stress through Activation of Autophagy. 2018 Dec 1
8 26471831 mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition. 2016 Jan 1
9 26937175 Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways. 2016 3
10 27070592 Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells. 2016 Apr 8 1
11 27616194 Rapamycin regulates the proliferation of Huh7, a hepatocellular carcinoma cell line, by up-regulating p53 expression. 2016 Oct 7 4
12 27825169 Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53. 2016 2
13 24915467 Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. 2014 Jul 5
14 25482947 mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. 2014 2
15 22559167 Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model. 2012 May 4 1
16 22710790 Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells. 2012 Sep 2
17 21945951 The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. 2011 Nov-Dec 1
18 20368736 BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing. 2010 Jun 1
19 20457898 Paradoxical suppression of cellular senescence by p53. 2010 May 25 1
20 20811722 Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status. 2010 Oct 1
21 18758183 P27 and P53 gene polymorphisms and restenosis following coronary implantation of drug-eluting stents. 2009 1
22 19261747 Inactivation of p53 and Pten promotes invasive bladder cancer. 2009 Mar 15 1
23 19337030 An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity. 2009 Jul 1
24 19815708 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. 2009 Nov 1
25 18604159 A dual role of p53 in the control of autophagy. 2008 Aug 1
26 18818522 Mutant p53 protein localized in the cytoplasm inhibits autophagy. 2008 Oct 1
27 18838865 p53 represses autophagy in a cell cycle-dependent fashion. 2008 Oct 1
28 16651424 Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. 2006 May 1 2
29 15218033 Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. 2004 Aug 27 1
30 12543789 Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. 2003 Jan 15 1
31 12820963 Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). 2003 Jun 1
32 11309295 p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. 2001 Apr 15 4
33 12030785 Mechanisms of resistance to rapamycins. 2001 Dec 1
34 10753954 Nitric oxide increases p21(Waf1/Cip1) expression by a cGMP-dependent pathway that includes activation of extracellular signal-regulated kinase and p70(S6k). 2000 Apr 14 2
35 10029080 Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. 1999 Feb 15 1
36 9865315 In vitro transcription and translation of the tumour suppressor protein P53: qualitative and quantitative effects of FK506 and rapamycin. 1998 Dec 1
37 21528311 Rapamycin-induced apoptosis is p53-independent in human prostate carcinoma PC-3 cells. 1997 Nov 1