Protein Name AKT serine/threonine kinase 1
Organism Rattus norvegicus
Gene ID 24185
Gene Symbol


UniProt P47196 (AKT1_RAT)
Relationships Total Number of functionally related compound(s) : 2385
Total Number of Articles : 5366

AKT serine/threonine kinase 1

Gene Summary

Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; cellular response to mechanical stimulus; and regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in cytosol; mitochondrion; and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; colon cancer; diabetic retinopathy; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); lung disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

  • RAC-alpha serine/threonine-protein kinase
  • AKT1 kinase
  • PKB alpha
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