Sirolimus

ribosomal protein S6 kinase B1 ; Homo sapiens







298 Article(s)
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1 34874016 mTOR inhibitor improves testosterone-induced myocardial hypertrophy in hypertensive rats. 2022 Jan 31 1
2 35078109 Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway. 2022 Feb 26 2
3 35149934 Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury. 2022 Mar 1
4 35176419 p70 S6 kinase as a therapeutic target in cancers: More than just an mTOR effector. 2022 Jun 1 1
5 35286973 The GLUT1-mTORC1 axis affects odontogenic differentiation of human dental pulp stem cells. 2022 Jun 1
6 35318320 S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions. 2022 Mar 22 1
7 35428493 Rapamycin induces autophagy and apoptosis in Kaposiform hemangioendothelioma primary cells in vitro. 2022 Jul 1
8 35447117 Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis. 2022 Apr 18 1
9 33189285 Acetate regulates milk fat synthesis through the mammalian target of rapamycin/eukaryotic initiation factor 4E signaling pathway in bovine mammary epithelial cells. 2021 Jan 1
10 33307758 An Insight into the Role of Apoptosis and Autophagy in Nitric Oxide-Induced Articular Chondrocyte Cell Death. 2021 Dec 1
11 33422633 Plasma from obese children increases monocyte-endothelial adhesion and affects intracellular insulin signaling in cultured endothelial cells: Potential role of mTORC1-S6K1. 2021 Apr 1 2
12 33609687 TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. 2021 May 15 1
13 33660929 Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy. 2021 Mar 1
14 33691148 Incomplete reminder cues trigger memory reconsolidation and sustain learned immune responses. 2021 Jul 2
15 33865602 Overexpression Prox1 in HemECs resembles Kaposiform hemangioendothelioma and cytotoxicity of sirolimus in vitro. 2021 Jul 1
16 33938392 mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. 2021 May 1
17 34004440 Metformin prevents BAFF activation of Erk1/2 from B-cell proliferation and survival by impeding mTOR-PTEN/Akt signaling pathway. 2021 Jul 1
18 34258253 Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation. 2021 Jun 30 1
19 34551966 TLR-4 Agonist Induces IFN-γ Production Selectively in Proinflammatory Human M1 Macrophages through the PI3K-mTOR- and JNK-MAPK-Activated p70S6K Pathway. 2021 Nov 1 1
20 34675258 TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs. 2021 Oct 21 1
21 34738031 Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances. 2021 Dec 1
22 34858182 Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension. 2021 1
23 31611063 Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice. 2020 Jan - Feb 1
24 31782083 Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1. 2020 Feb 2
25 31841452 α-Ketoglutarate Modulates Macrophage Polarization Through Regulation of PPARγ Transcription and mTORC1/p70S6K Pathway to Ameliorate ALI/ARDS. 2020 Jan 1
26 31863766 Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells. 2020 Feb 5 1
27 31896113 Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma. 2020 1
28 31931362 Dihydroartemisinin inhibits the proliferation of IgAN mesangial cells through the mTOR signaling pathway. 2020 Mar 1
29 32108266 Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes. 2020 Mar 1
30 32531316 Resveratrol potentiates the anti-tumor effects of rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved. 2020 Aug 15 1
31 32580379 Neuroprotection by Phytoestrogens in the Model of Deprivation and Resupply of Oxygen and Glucose In Vitro: The Contribution of Autophagy and Related Signaling Mechanisms. 2020 Jun 22 1
32 32599128 Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice. 2020 Sep 1
33 32621911 Exogenous supplement of glucagon like peptide-1 protects the heart against aortic banding induced myocardial fibrosis and dysfunction through inhibiting mTOR/p70S6K signaling and promoting autophagy. 2020 Sep 15 2
34 32707053 Upregulation of Rab31 is associated with poor prognosis and promotes colorectal carcinoma proliferation via the mTOR/p70S6K/Cyclin D1 signalling pathway. 2020 Sep 15 1
35 32922169 Rapamycin blocks the IL-13-induced deficiency of Epidermal Barrier Related Proteins via upregulation of miR-143 in HaCaT Keratinocytes. 2020 1
36 33490152 Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway. 2020 Dec 1
37 30552925 Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to rapamycin. 2019 Mar 15 3
38 30906437 Role of mTOR signaling in the regulation of high glucose-induced podocyte injury. 2019 Apr 1
39 30923227 Cannabinoid receptor 2 deletion deteriorates myocardial infarction through the down-regulation of AMPK-mTOR-p70S6K signaling-mediated autophagy. 2019 Apr 30 1
40 31133888 Mitochondrial Dysfunction Is Inducible in Lymphoblastoid Cell Lines From Children With Autism and May Involve the TORC1 Pathway. 2019 2
41 31383843 O-cyclic phytosphingosine-1-phosphate stimulates HIF1α-dependent glycolytic reprogramming to enhance the therapeutic potential of mesenchymal stem cells. 2019 Aug 5 1
42 31404320 Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway. 2019 Sep 4
43 31553107 Differentiation-inducing factor-1 suppresses cyclin D1-induced cell proliferation of MCF-7 breast cancer cells by inhibiting S6K-mediated signal transducer and activator of transcription 3 synthesis. 2019 Dec 1
44 31695068 Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease. 2019 Nov 6 2
45 28300280 Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells. 2018 Jan 1
46 29247557 Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. 2018 Apr 1
47 29270715 p70S6K activation promotes the transdifferentiation of fibroblasts to myofibroblasts in pterygium tissue growth on the cornea. 2018 Feb 1
48 29444470 Effect of sirolimus on liver cirrhosis and hepatic encephalopathy of common bile duct-ligated rats. 2018 Apr 5 1
49 29652799 Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. 2018 Apr 13 1
50 29872406 Tongguan Capsule Mitigates Post-myocardial Infarction Remodeling by Promoting Autophagy and Inhibiting Apoptosis: Role of Sirt1. 2018 1