Protein Name phosphatase and tensin homolog
Organism Homo sapiens
Gene ID 5728
Gene Symbol


UniProt P60484 (PTEN_HUMAN), F6KD01 (F6KD01_HUMAN)
Relationships Total Number of functionally related compound(s) : 1316
Total Number of Articles : 2610

phosphatase and tensin homolog

Gene Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

  • phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
  • MMAC1 phosphatase and tensin homolog deleted on chromosome 10
  • PTEN variant PTEN-K267Rfs*9
Click to show/hide the synonyms