| Protein Name | CD4 molecule |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 920 |
| Gene Symbol | CD4 |
| UniProt | P01730 (CD4_HUMAN), B4DT49 (B4DT49_HUMAN), A0A4Y5UGE4 (A0A4Y5UGE4_HUMAN), B0AZV7 (B0AZV7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
2744
Total Number of Articles : 6867 |
Description |
CD4 molecule |
| Gene Summary |
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020] |
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