Protein Name CD4 molecule
Organism Homo sapiens
Gene ID 920
Gene Symbol


UniProt P01730 (CD4_HUMAN), B4DT49 (B4DT49_HUMAN), A0A4Y5UGE4 (A0A4Y5UGE4_HUMAN), B0AZV7 (B0AZV7_HUMAN)
Relationships Total Number of functionally related compound(s) : 2744
Total Number of Articles : 6867

CD4 molecule

Gene Summary

This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]

  • T-cell surface glycoprotein CD4
  • CD4 antigen (p55)
  • CD4 receptor
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