Protein Name mechanistic target of rapamycin kinase
Organism Rattus norvegicus
Gene ID 56718
Gene Symbol


UniProt P42346 (MTOR_RAT)
Relationships Total Number of functionally related compound(s) : 809
Total Number of Articles : 1374

mechanistic target of rapamycin kinase

Gene Summary

Enables several functions, including protein kinase binding activity; protein serine/threonine kinase activity; and translation regulator activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of cellular protein metabolic process; and regulation of muscle adaptation. Acts upstream of or within cell projection organization and negative regulation of cell size. Located in cytosol and nucleus. Part of TORC1 complex. Is active in glutamatergic synapse and postsynaptic cytosol. Colocalizes with dendrite and neuronal cell body. Used to study several diseases, including artery disease (multiple); brain disease (multiple); crescentic glomerulonephritis; kidney failure (multiple); and muscular atrophy. Biomarker of several diseases, including middle cerebral artery infarction; obesity; type 2 diabetes mellitus; ureteral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2022]

  • serine/threonine-protein kinase mTOR
  • FK506 binding protein 12-rapamycin associated protein 1
  • FK506-binding protein 12-rapamycin complex-associated protein 1
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