Sirolimus

FKBP prolyl isomerase 1A ; Homo sapiens







31 Article(s)
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1 34191518 In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1. 2022 Jan 27 2
2 34989232 Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins. 2022 Jan 21 1
3 34342774 FK506-binding protein 2 (FKBP13) inhibit Bax-induced apoptosis in Saccharomyces cerevisiae (yeast). 2021 Aug 3 2
4 34712915 Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity. 2021 Nov 19 5
5 31862477 Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update. 2020 Feb 2
6 31894316 Anti‑proliferative effect of cardamonin on mTOR inhibitor‑resistant cancer cells. 2020 Mar 2
7 32298692 Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity. 2020 Jul 1
8 32422433 Regulation of the Ca2+-activated chloride channel Anoctamin-1 (TMEM16A) by Ca2+-induced interaction with FKBP12 and calcineurin. 2020 Jul 2
9 26490657 Effects of mTOR inhibitors and cytoskeletal-directed agents alone and in combination against normal and neoplastic hematopoietic cells in vitro. 2015 Dec 3
10 23252795 Adverse events associated with mTOR inhibitors. 2013 Mar 2
11 23957229 FK506-binding protein 12 ligands: a patent review. 2013 Nov 1
12 22708827 NEX-TRAP, a novel method for in vivo analysis of nuclear export of proteins. 2012 Oct 1
13 21073880 Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate. 2011 Jan 14 1
14 21138727 A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding. 2011 Apr 1 1
15 21541789 Clinical activity of mammalian target of rapamycin inhibitors in solid tumors. 2011 Jun 2
16 21851176 Rapamycin as an antiaging therapeutic?: targeting mammalian target of rapamycin to treat Hutchinson-Gilford progeria and neurodegenerative diseases. 2011 Aug 1
17 17438408 Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression. 2007 Apr 1
18 17524933 An assay for the determination of sirolimus levels in the lymphocyte of transplant patients. 2007 May 1
19 16405911 Structural characterization of the RyR1-FKBP12 interaction. 2006 Mar 3 1
20 14766396 The immunophilin FKBP12: a molecular guardian of the TGF-beta family type I receptors. 2004 Jan 1 1
21 15066126 Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. 2004 Apr 1
22 15284440 Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. 2004 Aug 17 1
23 11751303 FKBP12 modulation of the binding of the skeletal ryanodine receptor onto the II-III loop of the dihydropyridine receptor. 2002 Jan 1
24 11245643 Gene expression profiling of human stent-induced neointima by cDNA array analysis of microscopic specimens retrieved by helix cutter atherectomy: Detection of FK506-binding protein 12 upregulation. 2001 Mar 13 1
25 11510015 Orthotopic liver transplantation using low-dose tacrolimus and sirolimus. 2001 Aug 1
26 10777621 FKBP12 is a negative regulator of transforming growth factor-beta receptor internalization. 2000 Apr 28 1
27 9545268 Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. 1998 Apr 17 2
28 9145907 Noncoplanar PCB 95 alters microsomal calcium transport by an immunophilin FKBP12-dependent mechanism. 1997 May 2
29 8778023 Hypersensitivity to rapamycin of BJAB B lymphoblastoid cells. 1996 Mar 1
30 7536932 Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. 1995 Apr 11 2
31 1930186 Chromosomal assignment of the human immunophilin FKBP-12 gene. 1991 Sep 30 1