CPRiL

FKBP1A

FKBP prolyl isomerase 1A

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]

• peptidyl-prolyl cis-trans isomerase FKBP1A
• 12 kDa FK506-binding protein
• 12 kDa FKBP
FK506 binding protein 1A, 12kDa
FK506 binding protein12
FK506-binding protein 1
FK506-binding protein 12
FK506-binding protein 1A
FK506-binding protein, T-cell, 12-kD
FKBP12-Exip3
PPIase FKBP1A
calstabin-1
immunophilin FKBP12
protein kinase C inhibitor 2
rotamase
FKBP-12
FKBP-1A
FKBP1
FKBP12
PKC12
PKCI2
PPIASE