| 1 |
32738450 | p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma. | 2021 Jan |
1 |
| 2 |
33352197 | Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes. | 2021 Feb |
1 |
| 3 |
34253722 | TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. | 2021 Jul 12 |
2 |
| 4 |
34365025 | Chondrocyte Tsc1 controls cranial base bone development by restraining the premature differentiation of synchondroses. | 2021 Dec |
2 |
| 5 |
34677125 | mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia. | 2021 Oct 22 |
2 |
| 6 |
32375878 | Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice. | 2020 May 6 |
1 |
| 7 |
32484794 | Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex-associated cystic kidney disease. | 2020 Jul 9 |
2 |
| 8 |
32588887 | Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex. | 2020 Aug 11 |
2 |
| 9 |
32890589 | Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex. | 2020 Dec 1 |
1 |
| 10 |
33159078 | mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline. | 2020 Nov 6 |
1 |
| 11 |
30816216 | Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. | 2019 Feb 28 |
1 |
| 12 |
31078684 | Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex. | 2019 Sep |
1 |
| 13 |
31353861 | Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model. | 2019 Jul |
1 |
| 14 |
31433805 | TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. | 2019 Aug |
2 |
| 15 |
29396625 | TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms. | 2018 Jul |
1 |
| 16 |
29635516 | Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex. | 2018 Jun 15 |
1 |
| 17 |
30079598 | The specificity and role of microglia in epileptogenesis in mouse models of tuberous sclerosis complex. | 2018 Sep |
1 |
| 18 |
30185506 | TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury. | 2018 Oct 15 |
1 |
| 19 |
30247156 | Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss. | 2018 Nov 1 |
1 |
| 20 |
27524416 | mTOR promotes pituitary tumor development through activation of PTTG1. | 2017 Feb 16 |
1 |
| 21 |
28520214 | mTORC1 Inhibits NF-κB/NFATc1 Signaling and Prevents Osteoclast Precursor Differentiation, In Vitro and In Mice. | 2017 Sep |
1 |
| 22 |
28701517 | Mesangial Cell Mammalian Target of Rapamycin Complex 1 Activation Results in Mesangial Expansion. | 2017 Oct |
1 |
| 23 |
28775826 | A brain proteomic investigation of rapamycin effects in the Tsc1+/- mouse model. | 2017 |
6 |
| 24 |
28808237 | Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. | 2017 Aug 14 |
1 |
| 25 |
28844017 | Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1+/- Mice. | 2017 Oct |
1 |
| 26 |
28972182 | Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors. | 2017 Dec 15 |
1 |
| 27 |
26296742 | Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth. | 2016 Apr |
1 |
| 28 |
26655465 | Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. | 2016 Jan 26 |
1 |
| 29 |
26795955 | Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins. | 2016 Jan 22 |
4 |
| 30 |
26846849 | Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. | 2016 Apr 15 |
1 |
| 31 |
26991739 | Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension. | 2016 Sep |
1 |
| 32 |
27362797 | TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome. | 2016 Jun 30 |
1 |
| 33 |
25213336 | Tuberous sclerosis complex 1-mechanistic target of rapamycin complex 1 signaling determines brown-to-white adipocyte phenotypic switch. | 2015 Feb |
1 |
| 34 |
25613864 | Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation. | 2015 Feb 20 |
3 |
| 35 |
25646773 | Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt. | 2015 |
1 |
| 36 |
26122303 | Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex. | 2015 Jul |
2 |
| 37 |
26224859 | The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. | 2015 Jul 29 |
1 |
| 38 |
25082895 | Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21. | 2014 Aug 12 |
1 |
| 39 |
25288394 | Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. | 2014 Oct 20 |
1 |
| 40 |
23143994 | Deficiency in pulmonary surfactant proteins in mice with fatty acid binding protein 4-Cre-mediated knockout of the tuberous sclerosis complex 1 gene. | 2013 Mar |
1 |
| 41 |
23335988 | Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea. | 2013 |
1 |
| 42 |
23386687 | Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis. | 2013 May |
2 |
| 43 |
23661807 | Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. | 2013 Jun |
1 |
| 44 |
21062901 | Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. | 2011 Feb 1 |
1 |
| 45 |
21212099 | Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. | 2011 Apr 1 |
1 |
| 46 |
21890496 | Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. | 2011 Dec 1 |
2 |
| 47 |
19368729 | Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models. | 2009 Apr 15 |
3 |
| 48 |
18389497 | Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. | 2008 Apr |
4 |
| 49 |
17290308 | PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. | 2007 Mar |
1 |
| 50 |
16845661 | Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex. | 2006 Oct |
2 |