Protein Name interleukin 2
Organism Mus musculus
Gene ID 16183
Gene Symbol


UniProt P04351 (IL2_MOUSE)
Relationships Total Number of functionally related compound(s) : 1527
Total Number of Articles : 2660

interleukin 2

Gene Summary

Enables cytokine activity and interleukin-2 receptor binding activity. Involved in negative regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of macromolecule metabolic process; and regulation of lymphocyte activation. Located in extracellular space. Is expressed in liver; omental bursa; thymus; and thymus primordium. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Apr 2022]

  • interleukin-2
  • T-cell growth factor
  • TCGF
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