Sirolimus

interleukin 6 ; Homo sapiens







50 Article(s)
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Pub. Year
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1 34236783 Rapamycin and Paclitaxel Affect Human Aortic Smooth Muscle Cells-Derived Foam Cells Viability and Proliferation. 2022 May 2 1
2 34715309 Effects of miRNAs in exosomes derived from α-synuclein overexpressing SH-SY5Y cells on autophagy and inflammation of microglia. 2022 Jan 1
3 34936813 Mammalian Target of Rapamycin Inhibitor Rapamycin Alleviates 7-Ketocholesterol Induced Inflammatory Responses and Vascular Endothelial Growth Factor Elevation by Regulating MAPK Pathway in Human Retinal Pigment Epithelium Cells. 2022 Mar 1
4 35488725 Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO. 2022 Jun 1
5 35563682 Short-Term Autophagy Preconditioning Upregulates the Expression of COX2 and PGE2 and Alters the Immune Phenotype of Human Adipose-Derived Stem Cells In Vitro. 2022 Apr 19 3
6 35571122 Effect of Combined Mycophenolate and Rapamycin Treatment on Kidney Fibrosis in Murine Lupus Nephritis. 2022 1
7 33957967 Decreased microRNA-155 in Behcet's disease leads to defective control of autophagy thereby stimulating excessive proinflammatory cytokine production. 2021 May 6 1
8 34164408 HMGB1 Activates Myeloid Dendritic Cells by Up-Regulating mTOR Pathway in Systemic Lupus Erythematosus. 2021 1
9 31264496 Interruption of Autophagosome Formation in Cardiovascular Disease, an Evidence for Protective Response of Autophagy. 2020 Apr 1
10 32103032 p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells. 2020 Feb 26 2
11 32206779 Increased mTOR activation in idiopathic multicentric Castleman disease. 2020 May 7 1
12 32434116 Corrigendum to "Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation" [Mol. Immunol. 45 (2008) 2929-2936]. 2020 May 17 1
13 33031791 Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19. 2020 Nov 1 1
14 30703123 Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells. 2019 1
15 30747999 Curcumin reduces development of seizurelike events in the hippocampal-entorhinal cortex slice culture model for epileptogenesis. 2019 Apr 1
16 31645839 The mTOR kinase inhibitor rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human microglial cells. 2019 1
17 31885770 Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena. 2019 1
18 29348392 Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells. 2018 Jan 18 1
19 29772587 Anti-inflammatory Effects of Cardamonin in Ovarian Cancer Cells Are Mediated via mTOR Suppression. 2018 Nov 1
20 28804534 mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress. 2017 1
21 28894133 5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR. 2017 Sep 11 1
22 26879559 Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling. 2016 Feb 16 1
23 27350635 Th1, Th2 and Th17 Cytokine Profile in Patients with Multiple Sclerosis Following Treatment with Rapamycin. 2016 Jun 1
24 27871466 Autophagy protects against oxidized low density lipoprotein-mediated inflammation associated with preeclampsia. 2016 Dec 1
25 27904683 Rapamycin targets Interleukin 6 (IL-6) expression and suppresses endothelial cell invasion stimulated by tumor cells. 2016 2
26 25653476 Rapamycin improves palmitate-induced ER stress/NF κ B pathways associated with stimulating autophagy in adipocytes. 2015 1
27 25942007 mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. 2015 1
28 26652669 Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production. 2015 1
29 24910242 Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. 2014 Jul 1 2
30 23308138 Profiling sirolimus-induced inflammatory syndrome: a prospective tricentric observational study. 2013 1
31 22132896 Preconditioning donor with a combination of tacrolimus and rapamacyn to decrease ischaemia-reperfusion injury in a rat syngenic kidney transplantation model. 2012 Jan 1
32 20828737 Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline. 2011 Dec 1
33 19879324 p70 S6 kinase limits tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblast-like cells. 2010 Feb 5 1
34 20371718 Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma. 2010 Apr 1
35 20430366 Gingival overgrowth in cyclosporine, tacrolimus, or sirolimus-based immunosuppressive regimens and the single nucleotide IL-6 (-174 G/C) gene polymorphism. 2010 Jul 1
36 20844194 Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance. 2010 Oct 15 1
37 19131641 Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. 2009 Aug 1
38 17993646 Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. 2008 Jan 11 4
39 18343502 Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation. 2008 May 2
40 17322416 Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells. 2007 Jun 1
41 17880416 Effects of ciclosporin A, tacrolimus and sirolimus on cytokine production in neonatal immune cells. 2007 Oct 3
42 17996694 Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. 2007 Dec 15 1
43 16005497 Early elevation of interleukin-1beta and interleukin-6 levels after bare or drug-eluting stent implantation in patients with stable angina. 2006 1
44 15769938 Effects of sirolimus on mesangial cell cholesterol homeostasis: a novel mechanism for its action against lipid-mediated injury in renal allografts. 2005 Jul 1
45 15070696 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. 2004 Apr 15 2
46 11872747 Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6. 2002 May 3 3
47 9373220 Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells. 1997 Nov 4
48 8805102 In vitro effects of immunosuppressive agents on cytokine production by HTLV-I-infected T cell clones derived from the ocular fluid of patients with HTLV-I uveitis. 1996 1
49 8004821 Effects of cyclosporine and rapamycin on immunoglobulin production by preactivated human B cells. 1994 Jun 1
50 7507316 Immunosuppressants: tools to investigate the physiological role of cytokines. 1993 Nov 1