Protein Name eukaryotic translation initiation factor 4E
Organism Homo sapiens
Gene ID 1977
Gene Symbol

EIF4E

UniProt P06730 (IF4E_HUMAN), X5D7E3 (X5D7E3_HUMAN), D6RBW1 (D6RBW1_HUMAN), Q32Q75 (Q32Q75_HUMAN)
Relationships Total Number of functionally related compound(s) : 399
Total Number of Articles : 630
Description

eukaryotic translation initiation factor 4E

Gene Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

synonyms
  • eukaryotic translation initiation factor 4E
  • eIF-4F 25 kDa subunit
  • eukaryotic translation initiation factor 4E-like 1
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Properties