Simvastatin


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1653 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 3-hydroxy-3-methylglutaryl-CoA reductase HMDH_HUMAN HMGCR Homo sapiens 3156 571 210
2 cytochrome P450 family 3 subfamily A member 4 CP3A4_HUMAN CYP3A4 Homo sapiens 1576 3475 123
3 tumor necrosis factor TNFA_HUMAN TNF Homo sapiens 7124 8006 108
4 C-reactive protein CRP_HUMAN CRP Homo sapiens 1401 2285 89
5 apolipoprotein B APOB_HUMAN APOB Homo sapiens 338 1181 89
6 component of oligomeric golgi complex 2 COG2_HUMAN COG2 Homo sapiens 22796 427 88
7 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 80
8 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 70
9 solute carrier organic anion transporter family member 1B1 SO1B1_HUMAN SLCO1B1 Homo sapiens 10599 575 63
10 ras homolog family member A RHOA_HUMAN RHOA Homo sapiens 387 835 55
11 tumor necrosis factor TNFA_RAT Tnf Rattus norvegicus 24835 3922 54
12 low density lipoprotein receptor LDLR_HUMAN LDLR Homo sapiens 3949 826 44
13 3-hydroxy-3-methylglutaryl-CoA reductase HMDH_RAT Hmgcr Rattus norvegicus 25675 353 42
14 interleukin 1 beta IL1B_HUMAN IL1B Homo sapiens 3553 3575 41
15 matrix metallopeptidase 9 MMP9_HUMAN MMP9 Homo sapiens 4318 2470 39
16 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 39
17 insulin INS_HUMAN INS Homo sapiens 3630 7950 37
18 nuclear factor kappa B subunit 1 NFKB1_HUMAN NFKB1 Homo sapiens 4790 4834 35
19 C-C motif chemokine ligand 2 CCL2_HUMAN CCL2 Homo sapiens 6347 1858 34
20 apolipoprotein E APOE_MOUSE Apoe Mus musculus 11816 1371 34
21 C-X-C motif chemokine ligand 8 IL8_HUMAN CXCL8 Homo sapiens 3576 4038 33
22 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 31
23 AKT serine/threonine kinase 1 AKT1_RAT Akt1 Rattus norvegicus 24185 2385 30
24 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 29
25 vascular cell adhesion molecule 1 VCAM1_HUMAN VCAM1 Homo sapiens 7412 1154 29
26 serpin family E member 1 PAI1_HUMAN SERPINE1 Homo sapiens 5054 1182 28
27 angiotensinogen ANGT_RAT Agt Rattus norvegicus 24179 2598 28
28 3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMDH_MOUSE Hmgcr Mus musculus 15357 170 27
29 apolipoprotein A1 APOA1_HUMAN APOA1 Homo sapiens 335 1112 26
30 caspase 3 CASP3_RAT Casp3 Rattus norvegicus 25402 2178 26
31 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 26
32 interleukin 1 beta Q5BKB0_RAT Il1b Rattus norvegicus 24494 2252 26
33 transforming growth factor beta 1 TGFB1_HUMAN TGFB1 Homo sapiens 7040 2953 26
34 interferon gamma IFNG_HUMAN IFNG Homo sapiens 3458 3371 25
35 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 25
36 interleukin 6 IL6_RAT Il6 Rattus norvegicus 24498 2269 25
37 coagulation factor II, thrombin THRB_HUMAN F2 Homo sapiens 2147 4706 24
38 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 24
39 Rac family small GTPase 1 RAC1_HUMAN RAC1 Homo sapiens 5879 884 23
40 intercellular adhesion molecule 1 ICAM1_HUMAN ICAM1 Homo sapiens 3383 1840 23
41 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 22
42 mitogen-activated protein kinase 3 MK03_HUMAN MAPK3 Homo sapiens 5595 3238 22
43 vascular endothelial growth factor A VEGFA_RAT Vegfa Rattus norvegicus 83785 1424 22
44 nitric oxide synthase 3 NOS3_HUMAN NOS3 Homo sapiens 4846 1142 21
45 lipoprotein(a) - LPA Homo sapiens 4018 544 21
46 interleukin 6 IL6_MOUSE Il6 Mus musculus 16193 3985 21
47 latexin LXN_HUMAN LXN Homo sapiens 56925 5329 20
48 nitric oxide synthase 2 NOS2_RAT Nos2 Rattus norvegicus 24599 1861 20
49 matrix metallopeptidase 2 MMP2_HUMAN MMP2 Homo sapiens 4313 2342 19
50 bone gamma-carboxyglutamate protein OSTCN_HUMAN BGLAP Homo sapiens 632 987 18