Protein Name coagulation factor II, thrombin
Organism Homo sapiens
Gene ID 2147
Gene Symbol


UniProt P00734 (THRB_HUMAN)
Relationships Total Number of functionally related compound(s) : 4706
Total Number of Articles : 11746

coagulation factor II, thrombin

Gene Summary

This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020]

  • prothrombin
  • prepro-coagulation factor II
  • prothrombin B-chain
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