Simvastatin

coagulation factor II, thrombin ; Homo sapiens







24 Article(s)
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Pub. Year
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1 29916838 Simvastatin reverses multiple myeloma serum-induced prothrombotic phenotype in endothelial cells via ERK 1/2 signalling pathway. 2018 Sep 1
2 25861297 The influence of statin therapy on platelet activity markers in hyperlipidemic patients after ischemic stroke. 2015 Mar 16 1
3 21035882 Simvastatin administration reduces thromboxane production in subjects taking aspirin: links between aspirin resistance and thrombin generation. 2012 Jan 12 1
4 19631970 Prior simvastatin treatment is associated with reduced thrombin generation and platelet activation in patients with acute ST-segment elevation myocardial infarction. 2010 May 2
5 19014947 Berberine, a natural lipid-lowering drug, exerts prothrombotic effects on vascular cells. 2009 Feb 1
6 19027114 Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. 2009 Jun 1
7 18658277 Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition. 2008 Oct 4
8 17477084 [Estimation of the correlation between hemostatic parameters and serum lipids in patients with hyperlipidemia type II after simvastatin therapy]. 2007 Jan 2
9 16775505 Statins blunt thrombin-induced down-regulation of endothelial nitric oxide synthase expression in human endothelial cells. 2006 May 3
10 15853752 Statins and thrombin. 2005 Apr 1
11 15860737 Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells. 2005 Jul 1
12 15980269 Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients. 2005 Jul 1
13 16113803 Early antithrombotic and anti-inflammatory effects of simvastatin versus fenofibrate in patients with hypercholesterolemia. 2005 Jul 2
14 16521918 [Evaluation of thrombin generation and clot bound thrombin in plasma of hyperlipidemic patients treated with statins]. 2005 2
15 14630613 Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. 2004 May 2
16 11956113 Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. 2002 Apr 16 3
17 12067916 Rho-GTPase-dependent platelet-neutrophil interaction affected by HMG-CoA reductase inhibition with altered adenosine nucleotide release and function. 2002 Jun 1 1
18 11246536 Treatment with simvastatin and low-dose aspirin depresses thrombin generation in patients with coronary heart disease and borderline-high cholesterol levels. 2001 Feb 4
19 11342472 Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation. 2001 May 8 2
20 11687759 Antithrombotic actions of statins. 2001 Nov-Dec 1
21 10704621 Inhibition of tissue-factor-mediated thrombin generation by simvastatin. 2000 Mar 2
22 10830219 Simvastatin attenuates vascular hypercoagulability in cardiac transplant recipients. 2000 May 15 2
23 11104736 Simvastatin improves disturbed endothelial barrier function. 2000 Dec 5 2
24 10193729 Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia. 1999 Apr 3