Simvastatin

solute carrier organic anion transporter family member 1B1 ; Homo sapiens







63 Article(s)
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1 34403130 Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts. 2022 Feb 1
2 35169154 A population study of clinically actionable genetic variation affecting drug response from the Middle East. 2022 Feb 15 1
3 35543701 Pharmacogenomic Study of Statin-Associated Muscle Symptoms in the ODYSSEY OUTCOMES Trial. 2022 Jun 1
4 33277702 Statin-induced rhabdomyolysis from azithromycin interaction in a patient with heterozygous SLCO1B1 polymorphism. 2021 Jun 2
5 33280091 Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis. 2021 Jan 1
6 34114646 Effect of SLCO1B1 T521C on Statin-Related Myotoxicity With Use of Lovastatin and Atorvastatin. 2021 Sep 1
7 34606062 Role of Drug-Gene Interactions and Pharmacogenetics in Simvastatin-Associated Pulmonary Toxicity. 2021 Nov 3
8 34674552 Prevalence of protective haplotypes of the SLCO1B1 gene for statin transport in Mexican populations. 2021 Sep 1
9 31952675 Cost-Effectiveness of Multigene Pharmacogenetic Testing in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention. 2020 Jan 1
10 33270123 Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol: A Randomized Clinical Trial. 2020 Dec 1 5
11 30193394 The Association between Genetic Polymorphisms and Simvastatin-Induced Myopathy: A Narrative Synthesis of Evidence. 2019 Apr 1
12 31173123 Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users. 2019 Jun 5 1
13 29255993 Prevalence and nature of statin drug-drug interactions in a university hospital by electronic health record mining. 2018 Apr 1
14 29469964 Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics. 2018 Jun 1
15 30250148 Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis. 2018 Dec 1
16 30336686 Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia. 2018 Dec 4
17 27052517 Epigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats. 2017 Jan 1
18 27168098 Assessment of pharmacogenetic tests: presenting measures of clinical validity and potential population impact in association studies. 2017 Jul 1
19 28350522 The influences of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin, in relation to CYP3A4 inhibition. 2017 Apr 5
20 29181084 Clinical pharmacogenomics: patient perspectives of pharmacogenomic testing and the incidence of actionable test results in a chronic disease cohort. 2017 Sep 1
21 27307760 The frequency of SLCO1B1*5 polymorphism genotypes among Russian and Sakha (Yakutia) patients with hypercholesterolemia. 2016 1
22 27539103 Large copy-number variations in patients with statin-associated myopathy affecting statin myopathy-related loci. 2016 Dec 13 1
23 27606156 Association between SLCO1B1 -521T>C and -388A>G polymorphisms and risk of statin-induced adverse drug reactions: A meta-analysis. 2016 1
24 25379722 Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort. 2015 Jan 1
25 25673568 Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect? 2015 Mar 1
26 25992810 SLCO1B1 polymorphism is not associated with risk of statin-induced myalgia/myopathy in a Czech population. 2015 May 20 2
27 26020121 SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid. 2015 Aug 3
28 26164721 Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations. 2015 Jul 1
29 26329790 Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin. 2015 Nov 1
30 26367500 Impact of CYP2D6, CYP3A5, CYP2C19, CYP2A6, SLCO1B1, ABCB1, and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid. 2015 Dec 2
31 26376374 Association Between SLCO1B1 Gene T521C Polymorphism and Statin-Related Myopathy Risk: A Meta-Analysis of Case-Control Studies. 2015 Sep 1
32 24263182 The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study. 2014 Jan 1
33 24322971 Cardiovascular pharmacogenomics: expectations and practical benefits. 2014 Mar 1
34 24668570 No impact of SLCO1B1 521T>C, 388A>G and 411G>A polymorphisms on response to statin therapy in the Greek population. 2014 Jul 6
35 24918167 The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. 2014 Oct 2
36 24989890 Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data. 2014 Sep 1
37 25563221 Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients. 2014 Mar 27 1
38 23263738 Lack of association between SLCO1B1 polymorphism and the lipid-lowering effects of atorvastatin and simvastatin in Chinese individuals. 2013 Jun 1
39 23469684 Simvastatin pharmacokinetics in healthy Chinese subjects and its relations with CYP2C9, CYP3A5, ABCB1, ABCG2 and SLCO1B1 polymorphisms. 2013 Feb 1
40 23579966 Expanding role of pharmacogenomics in the management of cardiovascular disorders. 2013 Jun 2
41 23708174 Lack of association between SLCO1B1 polymorphisms and clinical myalgia following rosuvastatin therapy. 2013 Jun 1
42 23858814 Simvastatin-lnduced nocturnal leg pain disappears with pravastatin substitution. 2013 May-Jun 1
43 24459608 SLCO1B1 Polymorphisms and Statin-Induced Myopathy. 2013 Dec 4 1
44 21243006 Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin. 2012 Jun 5
45 21819236 Using genome-wide association studies to identify genes important in serious adverse drug reactions. 2012 1
46 21928084 SLCO1B1 haplotypes are not associated with atorvastatin-induced myalgia in Brazilian patients with familial hypercholesterolemia. 2012 Mar 2
47 22382501 Genetic determinants of response to cardiovascular drugs. 2012 May 1
48 22505549 SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians. 2012 Mar 4
49 22524173 Role of genetic factors in statins side-effects. 2012 Sep 1
50 22617227 The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. 2012 Jul 1