Protein Name bone gamma-carboxyglutamate protein
Organism Homo sapiens
Gene ID 632
Gene Symbol


UniProt P02818 (OSTCN_HUMAN)
Relationships Total Number of functionally related compound(s) : 987
Total Number of Articles : 2242

bone gamma-carboxyglutamate protein

Gene Summary

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

  • osteocalcin
  • bone gamma-carboxyglutamate (gla) protein (osteocalcin)
  • gamma-carboxyglutamic acid-containing protein
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