| Protein Name | bone gamma-carboxyglutamate protein |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 632 |
| Gene Symbol | BGLAP |
| UniProt | P02818 (OSTCN_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
987
Total Number of Articles : 2242 |
Description |
bone gamma-carboxyglutamate protein |
| Gene Summary |
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015] |
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