Simvastatin

tumor necrosis factor ; Homo sapiens







108 Article(s)
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1 34812477 Simvastatin inhibits the inflammation and oxidative stress of human neutrophils in sepsis via autophagy induction. 2022 Jan 1
2 35123844 Impact of oxidized LDL/LOX-1 system on ligamentum flavum hypertrophy. 2022 Feb 2 1
3 35308127 Beneficial effect of simvastatin on human umbilical vein endothelial cells gap junctions induced by TNF-α. 2022 1
4 33542676 Simvastatin Inhibits CYR61 Expression in Orbital Fibroblasts in Graves' Ophthalmopathy through the Regulation of FoxO3a Signaling. 2021 1
5 32892025 Di-(2-ethylhexyl) phthalate limits the pleiotropic effects of statins in chronic kidney disease patients undergoing dialysis and endothelial cells. 2020 Dec 1
6 31752013 Tumor Necrosis Factor-alpha (TNF-α) Enhances miR-155-Mediated Endothelial Senescence by Targeting Sirtuin1 (SIRT1). 2019 Nov 21 2
7 31969819 Modulation of Cytokine-Induced Astrocytic Endothelin-1 Production as a Possible New Approach to the Treatment of Multiple Sclerosis. 2019 1
8 29389739 Simvastatin Modulates Interaction Between Vascular Smooth Muscle Cell/Macrophage and TNF-α-Activated Endothelial Cell. 2018 May 4
9 29604489 Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. 2018 May 6
10 29911323 Regulation of p38 mitogen-activated kinase-mediated fetal membrane senescence by statins. 2018 Oct 1
11 28546421 Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism. 2017 Sep 1
12 29250545 Efficacy and Mechanism of Preoperative Simvastatin Therapy on Myocardial Protection after Extracorporeal Circulation. 2017 1
13 26884289 Age may determine the effect of hypolipidemic agents on plasma adipokine levels in patients with elevated low-density lipoprotein cholesterol levels. 2016 1
14 26884290 The effect of hypolipidemic treatment on monocyte cytokine release in different age groups of patients with type 2 diabetes and atherogenic dyslipidemia. 2016 1
15 26911804 Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia. 2016 Oct 1
16 27086089 Perioperative Simvastatin Therapy in Major Colorectal Surgery: A Prospective, Double-Blind Randomized Controlled Trial. 2016 Aug 1
17 27213056 Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease. 2016 1
18 27650878 Oxidized Low-Density Lipoprotein (OxLDL)-Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let-7c Is Integral to the Effect. 2016 Sep 20 1
19 27818195 Lipophilic but not hydrophilic statin functionally inhibit volume-activated chloride channels by inhibiting NADPH oxidase in monocytes. 2016 Dec 2 1
20 25704622 The Effect of Simvastatin on Infection-Induced Inflammatory Response of Human Fetal Membranes. 2015 Jul 3
21 25931040 Comparison of the effects of short-term hypolipidaemic treatment on plasma adipokine levels in men and women with isolated hypercholesterolaemia. 2015 1
22 25993292 Inhibitory effect of statins on inflammation-related pathways in human abdominal aortic aneurysm tissue. 2015 May 18 2
23 26091905 The effect of simvastatin treatment on endothelial cell response to shear stress and tumor necrosis factor alpha stimulation. 2015 Jun 20 1
24 26136131 Comparison of the effects of hypolipidemic treatment on monocyte proinflammatory cytokine release in men and women with type 2 diabetes and atherogenic dyslipidemia. 2015 3
25 26322850 Simvastatin Inhibits Toll-like Receptor 8 (TLR8) Signaling in Primary Human Monocytes and Spontaneous Tumor Necrosis Factor Production from Rheumatoid Synovial Membrane Cultures. 2015 Nov 2
26 27012115 Tobacco smoking, paraoxonase-1 (PON1) activity and pleiotropic effects of simvastatin treatment in patients with stable coronary artery disease (CAD). 2015 1
27 24354929 The effect of simvastatin-ezetimibe combination therapy on adipose tissue hormones and systemic inflammation in patients with isolated hypercholesterolemia. 2014 Apr 1
28 24392131 Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-κB activation. 2014 1
29 24718722 Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1. 2014 Jul 4
30 24788303 Simvastatin modulates cellular components in influenza A virus-infected cells. 2014 Jul 1
31 25149995 The effect of short-term simvastatin treatment on plasma adipokine levels in patients with isolated hypercholesterolemia: A preliminary report. 2014 Oct 1
32 25185849 The effect of short-term combined treatment with simvastatin and ezetimibe on circulating adipokine levels in patients with isolated hypercholesterolemia. 2014 1
33 22915623 Simvastatin inhibits the pro-inflammatory and pro-thrombotic effects of IL-17 and TNF-α on endothelial cells. 2013 May 4
34 23159435 Monocyte-suppressing effects of simvastatin in patients with isolated hypertriglyceridemia. 2013 Apr 1
35 23250325 Simvastatin abrogates inflamed neutrophil adhesive properties, in association with the inhibition of Mac-1 integrin expression and modulation of Rho kinase activity. 2013 Feb 1
36 23376721 Simvastatin inhibits ox-LDL-induced inflammatory adipokines secretion via amelioration of ER stress in 3T3-L1 adipocyte. 2013 Mar 8 2
37 23950601 Lymphocyte-suppressing action of simvastatin in patients with isolated hypertriglyceridemia. 2013 1
38 24028188 Cdc42 GTPases facilitate TNF-α-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells. 2013 Sep 1
39 22405819 Effect of shear stress, statins and TNF-α on hemostatic genes in human endothelial cells. 2012 Mar 30 2
40 22658637 TNF-α modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes. 2012 Oct 2
41 22694979 Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB. 2012 Aug 2
42 22974127 Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis. 2012 Sep 14 1
43 23108656 Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. 2012 Dec 2
44 20473500 HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients. 2011 Nov 1
45 20607595 Effects of simvastatin on proinflammatory cytokines and matrix metalloproteinases in hypercholesterolemic individuals. 2011 Aug 1
46 21173096 Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin. 2011 Apr 2
47 21276586 Effect of simvastatin and fenofibrate on cytokine release and systemic inflammation in type 2 diabetes mellitus with mixed dyslipidemia. 2011 Apr 1 1
48 21367616 Effects of simvastatin on cytokines secretion from mononuclear cells from critically ill patients with acute kidney injury. 2011 May 2
49 21925249 Simvastatin inhibits pro-inflammatory mediators through induction of heme oxygenase-1 expression in lipopolysaccharide-stimulated RAW264.7 macrophages. 2011 Nov 30 2
50 22027793 [Rosuvastatin improves myocardial function and arteriosclerosis plaque in patients with ST-segment elevation after acute myocardial infarction and percutaneous coronary intervention]. 2011 Oct 1