Protein Name 3-hydroxy-3-methylglutaryl-CoA reductase
Organism Rattus norvegicus
Gene ID 25675
Gene Symbol


UniProt P51639 (HMDH_RAT)
Relationships Total Number of functionally related compound(s) : 353
Total Number of Articles : 634

3-hydroxy-3-methylglutaryl-CoA reductase

Gene Summary

Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Located in intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]

  • 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  • HMG-CoA reductase
  • 3H3M
Click to show/hide the synonyms