| Protein Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25675 |
| Gene Symbol | Hmgcr |
| UniProt | P51639 (HMDH_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
353
Total Number of Articles : 634 |
Description |
3-hydroxy-3-methylglutaryl-CoA reductase |
| Gene Summary |
Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025] |
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