Simvastatin

C-C motif chemokine ligand 2 ; Homo sapiens







34 Article(s)
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1 32153409 Pleiotropic Effects of Simvastatin on the Regulation of Potassium Channels in Monocytes. 2020 2
2 32418888 Attenuation of the pro-inflammatory signature of lung cancer-derived mesenchymal stromal cells by statins. 2020 Aug 1 2
3 30100024 Simvastatin reduces the TLR4-induced inflammatory response in human aortic valve interstitial cells. 2018 Oct 1
4 28950844 Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial. 2017 Sep 26 3
5 25374119 Simvastatin attenuates angiotensin II‑induced inflammation and oxidative stress in human mesangial cells. 2015 Feb 1
6 26136131 Comparison of the effects of hypolipidemic treatment on monocyte proinflammatory cytokine release in men and women with type 2 diabetes and atherogenic dyslipidemia. 2015 3
7 23817506 Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial. 2014 Jan 1
8 24135266 Simvastatin reduces CCL2 expression in monocyte-derived cells by induction of a repressive CCL2 chromatin state. 2014 Jan 4
9 24684779 Synergistic anti-inflammatory effect: simvastatin and pioglitazone reduce inflammatory markers of plasma and epicardial adipose tissue of coronary patients with metabolic syndrome. 2014 Mar 31 1
10 25331390 [Multiple effect of simvastatin on vascular endothelium of hypercholesterolemia patients]. 2014 Oct 18 1
11 23159435 Monocyte-suppressing effects of simvastatin in patients with isolated hypertriglyceridemia. 2013 Apr 1
12 23376721 Simvastatin inhibits ox-LDL-induced inflammatory adipokines secretion via amelioration of ER stress in 3T3-L1 adipocyte. 2013 Mar 8 2
13 24028188 Cdc42 GTPases facilitate TNF-α-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells. 2013 Sep 1
14 22658637 TNF-α modulates statin effects on secretion and expression of MCP-1, PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes. 2012 Oct 1
15 21276586 Effect of simvastatin and fenofibrate on cytokine release and systemic inflammation in type 2 diabetes mellitus with mixed dyslipidemia. 2011 Apr 1 1
16 21345291 Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. 2011 Jan-Feb 4
17 19151033 Statins inhibit C-reactive protein-induced chemokine secretion, ICAM-1 upregulation and chemotaxis in adherent human monocytes. 2009 Mar 1
18 19252096 Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. 2009 May 1
19 17399814 Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients by decreasing the serum levels of monocyte chemoattractant protein-1. 2008 Feb 29 4
20 18192240 Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2. 2008 Apr 1 3
21 17261959 Impact of simvastatin and losartan on antiinflammatory effect: in vitro study. 2007 Jan 2
22 18036447 Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial. 2007 Nov 27 1
23 16321392 Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. 2006 Sep 1
24 16729291 Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. 2006 Jul 2
25 16781696 The expression of monocyte chemoattractant protein-1 and C-C chemokine receptor 2 in post-kidney transplant patients and the influence of simvastatin treatment. 2006 Nov 2
26 15781755 HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. 2005 Mar 22 3
27 15488877 Vascular effects of simvastatin combined with ramipril in hypercholesterolemic patients with coronary artery disease, compared with simvastatin alone: a randomized, double-blind, placebo-controlled, crossover study. 2004 Nov 2
28 12756509 Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia. 2003 Jul 4
29 12805493 Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis. 2003 Jul 1
30 12816176 Effects of fenofibrate and simvastatin on plasma sICAM-1 and MCP-1 concentrations in patients with hyperlipoproteinemia. 2003 Jun 1
31 12117737 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. 2002 Jul 1 2
32 11382718 Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. 2001 May 29 1
33 11404382 Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation. 2001 Jun 1
34 10908155 Inhibition of monocyte chemotactic protein-1 synthesis by statins. 2000 Jul 1