| Protein Name | caspase 3 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25402 |
| Gene Symbol | Casp3 |
| UniProt | P55213 (CASP3_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
2178
Total Number of Articles : 5110 |
Description |
caspase 3 |
| Gene Summary |
Enables several functions, including death receptor binding activity; phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including luteolysis; nervous system development; and positive regulation of amyloid-beta formation. Located in cytosol; membrane raft; and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach cancer. Orthologous to human CASP3 (caspase 3). [provided by Alliance of Genome Resources, Apr 2022] |
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