Protein Name nitric oxide synthase 2
Organism Rattus norvegicus
Gene ID 24599
Gene Symbol


UniProt Q06518 (NOS2_RAT)
Relationships Total Number of functionally related compound(s) : 1861
Total Number of Articles : 4028

nitric oxide synthase 2

Gene Summary

Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; cellular response to cytokine stimulus; and response to bacterium. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

  • nitric oxide synthase, inducible
  • NOS type II
  • inducible NO synthase
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