Protein Name ras homolog family member A
Organism Homo sapiens
Gene ID 387
Gene Symbol


UniProt P61586 (RHOA_HUMAN), A0A024R324 (A0A024R324_HUMAN), C9JX21 (C9JX21_HUMAN), A0A7I2YQV1 (A0A7I2YQV1_HUMAN), C9JRM1 (C9JRM1_HUMAN), B4DKN9 (B4DKN9_HUMAN), Q9BVT0 (Q9BVT0_HUMAN)
Relationships Total Number of functionally related compound(s) : 835
Total Number of Articles : 1808

ras homolog family member A

Gene Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

  • transforming protein RhoA
  • Aplysia ras-related homolog 12
  • epididymis secretory sperm binding protein
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