Sorafenib


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1458 Functionally related protein(s)
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Protein Name
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UniProt Entry
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Gene Symbol
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Organism
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NCBI Gene ID
# All related compound(s)
#Article(s)
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1 kinase insert domain receptor VGFR2_HUMAN KDR Homo sapiens 3791 1635 244
2 vascular endothelial growth factor A VEGFA_HUMAN VEGFA Homo sapiens 7422 4023 220
3 fms related receptor tyrosine kinase 3 FLT3_HUMAN FLT3 Homo sapiens 2322 569 202
4 zinc fingers and homeoboxes 2 ZHX2_HUMAN ZHX2 Homo sapiens 22882 627 201
5 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 154
6 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 153
7 B-Raf proto-oncogene, serine/threonine kinase BRAF_HUMAN BRAF Homo sapiens 673 872 105
8 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 95
9 mitogen-activated protein kinase kinase 7 MP2K7_HUMAN MAP2K7 Homo sapiens 5609 1407 92
10 platelet derived growth factor receptor beta PGFRB_HUMAN PDGFRB Homo sapiens 5159 417 86
11 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 85
12 HCC - HCC Homo sapiens 619501 252 85
13 Raf-1 proto-oncogene, serine/threonine kinase RAF1_HUMAN RAF1 Homo sapiens 5894 636 75
14 signal transducer and activator of transcription 3 STAT3_HUMAN STAT3 Homo sapiens 6774 2503 71
15 KIT proto-oncogene, receptor tyrosine kinase KIT_HUMAN KIT Homo sapiens 3815 679 68
16 alpha fetoprotein FETA_HUMAN AFP Homo sapiens 174 935 56
17 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 53
18 MIR7-3 host gene - MIR7-3HG Homo sapiens 284424 679 46
19 ret proto-oncogene RET_HUMAN RET Homo sapiens 5979 674 46
20 BCL2 apoptosis regulator BCL2_HUMAN BCL2 Homo sapiens 596 4403 45
21 mitogen-activated protein kinase 3 MK03_HUMAN MAPK3 Homo sapiens 5595 3238 45
22 caspase 3 CASP3_HUMAN CASP3 Homo sapiens 836 5209 40
23 BH3 interacting domain death agonist BID_HUMAN BID Homo sapiens 637 1130 33
24 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 29
25 catenin beta 1 CTNB1_HUMAN CTNNB1 Homo sapiens 1499 2350 28
26 eukaryotic translation initiation factor 2 alpha kinase 3 E2AK3_HUMAN EIF2AK3 Homo sapiens 9451 737 28
27 mitogen-activated protein kinase 8 MK08_HUMAN MAPK8 Homo sapiens 5599 2863 28
28 nuclear factor kappa B subunit 1 NFKB1_HUMAN NFKB1 Homo sapiens 4790 4834 27
29 cytochrome P450 family 3 subfamily A member 4 CP3A4_HUMAN CYP3A4 Homo sapiens 1576 3475 27
30 latexin LXN_HUMAN LXN Homo sapiens 56925 5329 27
31 EPH receptor B2 EPHB2_HUMAN EPHB2 Homo sapiens 2048 321 26
32 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 26
33 fms related receptor tyrosine kinase 1 VGFR1_HUMAN FLT1 Homo sapiens 2321 547 25
34 BCL2 associated X, apoptosis regulator BAX_HUMAN BAX Homo sapiens 581 3031 25
35 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 24
36 TNF superfamily member 10 TNF10_HUMAN TNFSF10 Homo sapiens 8743 1439 23
37 hypoxia inducible factor 1 subunit alpha HIF1A_HUMAN HIF1A Homo sapiens 3091 2152 23
38 fms related receptor tyrosine kinase 4 VGFR3_HUMAN FLT4 Homo sapiens 2324 142 23
39 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 22
40 mitogen-activated protein kinase 14 MK14_HUMAN MAPK14 Homo sapiens 1432 3132 22
41 heparan sulfate proteoglycan 2 PGBM_HUMAN HSPG2 Homo sapiens 3339 545 22
42 ATP binding cassette subfamily B member 1 MDR1_HUMAN ABCB1 Homo sapiens 5243 3985 22
43 mitogen-activated protein kinase 1 MK01_MOUSE Mapk1 Mus musculus 26413 1992 21
44 MET proto-oncogene, receptor tyrosine kinase MET_HUMAN MET Homo sapiens 4233 791 21
45 interleukin 6 IL6_HUMAN IL6 Homo sapiens 3569 5444 21
46 transforming growth factor beta 1 TGFB1_HUMAN TGFB1 Homo sapiens 7040 2953 19
47 NFE2 like bZIP transcription factor 2 NF2L2_HUMAN NFE2L2 Homo sapiens 4780 2545 19
48 ATP binding cassette subfamily G member 2 (Junior blood group) ABCG2_HUMAN ABCG2 Homo sapiens 9429 1370 18
49 platelet derived growth factor receptor alpha PGFRA_HUMAN PDGFRA Homo sapiens 5156 229 17
50 hepatocyte growth factor HGF_HUMAN HGF Homo sapiens 3082 1036 16