Protein Name hepatocyte growth factor
Organism Homo sapiens
Gene ID 3082
Gene Symbol


UniProt P14210 (HGF_HUMAN)
Relationships Total Number of functionally related compound(s) : 1036
Total Number of Articles : 1657

hepatocyte growth factor

Gene Summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

  • hepatocyte growth factor
  • fibroblast-derived tumor cytotoxic factor
  • hepatocyte growth factor (hepapoietin A; scatter factor)
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