CPRiL

KDR

kinase insert domain receptor

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

• vascular endothelial growth factor receptor 2
• fetal liver kinase-1
• kinase insert domain receptor (a type III receptor tyrosine kinase)
protein-tyrosine kinase receptor Flk-1
soluble VEGFR2
tyrosine kinase growth factor receptor
CD309
FLK1
VEGFR
VEGFR2