Protein Name kinase insert domain receptor
Organism Homo sapiens
Gene ID 3791
Gene Symbol


UniProt P35968 (VGFR2_HUMAN)
Relationships Total Number of functionally related compound(s) : 1635
Total Number of Articles : 3038

kinase insert domain receptor

Gene Summary

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

  • vascular endothelial growth factor receptor 2
  • fetal liver kinase-1
  • kinase insert domain receptor (a type III receptor tyrosine kinase)
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