Protein Name catenin beta 1
Organism Homo sapiens
Gene ID 1499
Gene Symbol


UniProt P35222 (CTNB1_HUMAN), A0A024R2Q3 (A0A024R2Q3_HUMAN), B4DGU4 (B4DGU4_HUMAN)
Relationships Total Number of functionally related compound(s) : 2350
Total Number of Articles : 5038

catenin beta 1

Gene Summary

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

  • catenin beta-1
  • catenin (cadherin-associated protein), beta 1, 88kDa
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