Protein Name mitogen-activated protein kinase kinase 7
Organism Homo sapiens
Gene ID 5609
Gene Symbol


UniProt O14733 (MP2K7_HUMAN), B4DV95 (B4DV95_HUMAN)
Relationships Total Number of functionally related compound(s) : 1407
Total Number of Articles : 4196

mitogen-activated protein kinase kinase 7

Gene Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

  • dual specificity mitogen-activated protein kinase kinase 7
  • JNK-activating kinase 2
  • MAP kinase kinase 7
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