CPRiL

MAP2K7

mitogen-activated protein kinase kinase 7

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

• dual specificity mitogen-activated protein kinase kinase 7
• JNK-activating kinase 2
• MAP kinase kinase 7
MAPK/ERK kinase 7
SAPK kinase 4
c-Jun N-terminal kinase kinase 2
stress-activated protein kinase kinase 4
JNKK2
MAPKK7
MEK
MEK 7
MKK7
PRKMK7
SAPKK-4
SAPKK4