Protein Name fms related receptor tyrosine kinase 3
Organism Homo sapiens
Gene ID 2322
Gene Symbol

FLT3

UniProt P36888 (FLT3_HUMAN)
Relationships Total Number of functionally related compound(s) : 569
Total Number of Articles : 1259
Description

fms related receptor tyrosine kinase 3

Gene Summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

synonyms
  • receptor-type tyrosine-protein kinase FLT3
  • CD135 antigen
  • FL cytokine receptor
Click to show/hide the synonyms
Properties