Protein Name ret proto-oncogene
Organism Homo sapiens
Gene ID 5979
Gene Symbol


UniProt P07949 (RET_HUMAN), A0A024R7T2 (A0A024R7T2_HUMAN)
Relationships Total Number of functionally related compound(s) : 674
Total Number of Articles : 1409

ret proto-oncogene

Gene Summary

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]

  • proto-oncogene tyrosine-protein kinase receptor Ret
  • RET receptor tyrosine kinase
  • cadherin family member 12
Click to show/hide the synonyms