Protein Name Raf-1 proto-oncogene, serine/threonine kinase
Organism Homo sapiens
Gene ID 5894
Gene Symbol


UniProt P04049 (RAF1_HUMAN), L7RRS6 (L7RRS6_HUMAN), A0A0S2Z4L5 (A0A0S2Z4L5_HUMAN)
Relationships Total Number of functionally related compound(s) : 636
Total Number of Articles : 1083

Raf-1 proto-oncogene, serine/threonine kinase

Gene Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

  • RAF proto-oncogene serine/threonine-protein kinase
  • C-Raf proto-oncogene, serine/threonine kinase
  • Oncogene RAF1
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