| Protein Name | BH3 interacting domain death agonist |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 637 |
| Gene Symbol | BID |
| UniProt | P55957 (BID_HUMAN), B2ZP79 (B2ZP79_HUMAN), A8ASI8 (A8ASI8_HUMAN), B3KT21 (B3KT21_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1130
Total Number of Articles : 2099 |
Description |
BH3 interacting domain death agonist |
| Gene Summary |
This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Aug 2020] |
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