Protein Name mitogen-activated protein kinase 8
Organism Homo sapiens
Gene ID 5599
Gene Symbol


UniProt P45983 (MK08_HUMAN), A1L4K2 (A1L4K2_HUMAN)
Relationships Total Number of functionally related compound(s) : 2863
Total Number of Articles : 6902

mitogen-activated protein kinase 8

Gene Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

  • mitogen-activated protein kinase 8
  • JUN N-terminal kinase
  • MAP kinase 8
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