Protein Name eukaryotic translation initiation factor 2 alpha kinase 3
Organism Homo sapiens
Gene ID 9451
Gene Symbol


UniProt Q9NZJ5 (E2AK3_HUMAN), B3KY45 (B3KY45_HUMAN), Q68DI6 (Q68DI6_HUMAN)
Relationships Total Number of functionally related compound(s) : 737
Total Number of Articles : 1121

eukaryotic translation initiation factor 2 alpha kinase 3

Gene Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

  • eukaryotic translation initiation factor 2-alpha kinase 3
  • PKR-like ER kinase
  • PRKR-like endoplasmic reticulum kinase
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