Protein Name | eukaryotic translation initiation factor 2 alpha kinase 3 |
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Organism | Homo sapiens |
Gene ID | 9451 |
Gene Symbol | EIF2AK3 |
UniProt | Q9NZJ5 (E2AK3_HUMAN), B3KY45 (B3KY45_HUMAN), Q68DI6 (Q68DI6_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
737
Total Number of Articles : 1121 |
Description |
eukaryotic translation initiation factor 2 alpha kinase 3 |
Gene Summary |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
synonyms |
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Properties | |